ID MFS6L_HUMAN Reviewed; 586 AA.
AC Q8IWD5; Q6YL34; Q8NA76;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 24-JAN-2024, entry version 120.
DE RecName: Full=Major facilitator superfamily domain-containing protein 6-like;
GN Name=MFSD6L; ORFNames=FP7072;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM98769.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY129026; AAM98769.1; ALT_FRAME; mRNA.
DR EMBL; AK093092; BAC04050.1; -; mRNA.
DR EMBL; BC040487; AAH40487.1; -; mRNA.
DR CCDS; CCDS11146.1; -.
DR RefSeq; NP_689812.3; NM_152599.3.
DR AlphaFoldDB; Q8IWD5; -.
DR BioGRID; 127814; 17.
DR STRING; 9606.ENSP00000330051; -.
DR TCDB; 2.A.1.65.10; the major facilitator superfamily (mfs).
DR GlyGen; Q8IWD5; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8IWD5; -.
DR PhosphoSitePlus; Q8IWD5; -.
DR BioMuta; MFSD6L; -.
DR DMDM; 190360169; -.
DR MassIVE; Q8IWD5; -.
DR PaxDb; 9606-ENSP00000330051; -.
DR PeptideAtlas; Q8IWD5; -.
DR ProteomicsDB; 70847; -.
DR TopDownProteomics; Q8IWD5; -.
DR Antibodypedia; 12633; 16 antibodies from 10 providers.
DR DNASU; 162387; -.
DR Ensembl; ENST00000329805.6; ENSP00000330051.4; ENSG00000185156.6.
DR GeneID; 162387; -.
DR KEGG; hsa:162387; -.
DR MANE-Select; ENST00000329805.6; ENSP00000330051.4; NM_152599.4; NP_689812.3.
DR UCSC; uc002glp.3; human.
DR AGR; HGNC:26656; -.
DR CTD; 162387; -.
DR GeneCards; MFSD6L; -.
DR HGNC; HGNC:26656; MFSD6L.
DR HPA; ENSG00000185156; Tissue enhanced (pancreas, testis).
DR neXtProt; NX_Q8IWD5; -.
DR PharmGKB; PA164722299; -.
DR VEuPathDB; HostDB:ENSG00000185156; -.
DR eggNOG; KOG3762; Eukaryota.
DR GeneTree; ENSGT00530000063599; -.
DR HOGENOM; CLU_013133_4_0_1; -.
DR InParanoid; Q8IWD5; -.
DR OMA; YEYLDFA; -.
DR OrthoDB; 5406687at2759; -.
DR PhylomeDB; Q8IWD5; -.
DR TreeFam; TF314366; -.
DR PathwayCommons; Q8IWD5; -.
DR BioGRID-ORCS; 162387; 8 hits in 1140 CRISPR screens.
DR ChiTaRS; MFSD6L; human.
DR GenomeRNAi; 162387; -.
DR Pharos; Q8IWD5; Tdark.
DR PRO; PR:Q8IWD5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8IWD5; Protein.
DR Bgee; ENSG00000185156; Expressed in left testis and 62 other cell types or tissues.
DR Genevisible; Q8IWD5; HS.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR CDD; cd17479; MFS_MFSD6L; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF22; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..586
FT /note="Major facilitator superfamily domain-containing
FT protein 6-like"
FT /id="PRO_0000321944"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 133..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 486
FT /note="R -> H (in dbSNP:rs2242373)"
FT /id="VAR_039389"
FT CONFLICT 214
FT /note="P -> T (in Ref. 3; AAH40487)"
FT /evidence="ECO:0000305"
FT CONFLICT 277
FT /note="F -> S (in Ref. 2; BAC04050)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 586 AA; 64005 MW; AF1607041015758D CRC64;
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT LMGTKHLIAA
FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV DKNRVHFPCN GSSGLTSTDA
LPGVTLPVNI TSAQESASSH PAKRTAEVEM PGFRNPPGES DRETFRDLHV YLAPSVEGAR
TTSQALLHPV TSGLKDHPWE VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE
ALRRTFILSL GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE PSYKRVKALS
IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE LVMGFSVALS LLGEILLHPF
KATLLRKLSR TGLVGLGLSC LAGQLLYYSF LWSWWSVLPI QILSAISNRA LWWAVGASVE
DLATPRMERA LSALFRGHFY GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS
IQRRLPRERK IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD
//
