ID MLO5_ARATH Reviewed; 501 AA.
AC O22815;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 131.
DE RecName: Full=MLO-like protein 5;
DE Short=AtMlo5;
GN Name=MLO5; OrderedLocusNames=At2g33670; ORFNames=F4P9.44, T1B8.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
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DR EMBL; AF369566; AAK53798.1; -; mRNA.
DR EMBL; AC002332; AAM14803.1; -; Genomic_DNA.
DR EMBL; U78721; AAC69142.3; -; Genomic_DNA.
DR EMBL; CP002685; AEC08867.1; -; Genomic_DNA.
DR PIR; B84748; B84748.
DR RefSeq; NP_180923.1; NM_128925.2.
DR AlphaFoldDB; O22815; -.
DR BioGRID; 3279; 13.
DR IntAct; O22815; 13.
DR STRING; 3702.O22815; -.
DR TCDB; 1.A.130.1.12; the mildew-resistance locus o (mlo) family.
DR iPTMnet; O22815; -.
DR PaxDb; 3702-AT2G33670-1; -.
DR ProteomicsDB; 238712; -.
DR EnsemblPlants; AT2G33670.1; AT2G33670.1; AT2G33670.
DR GeneID; 817932; -.
DR Gramene; AT2G33670.1; AT2G33670.1; AT2G33670.
DR KEGG; ath:AT2G33670; -.
DR Araport; AT2G33670; -.
DR TAIR; AT2G33670; MLO5.
DR eggNOG; ENOG502QPZ5; Eukaryota.
DR HOGENOM; CLU_024720_1_0_1; -.
DR InParanoid; O22815; -.
DR OMA; ELMIHKI; -.
DR OrthoDB; 368831at2759; -.
DR PhylomeDB; O22815; -.
DR PRO; PR:O22815; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22815; baseline and differential.
DR Genevisible; O22815; AT.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0043621; F:protein self-association; IPI:TAIR.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0010183; P:pollen tube guidance; IGI:TAIR.
DR GO; GO:0072659; P:protein localization to plasma membrane; IGI:TAIR.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR31942:SF53; MLO-LIKE PROTEIN 5-RELATED; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..501
FT /note="MLO-like protein 5"
FT /id="PRO_0000209935"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..151
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..501
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 443..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..471
FT /note="Calmodulin-binding"
FT COMPBIAS 474..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 458
FT /note="Missing (in Ref. 1; AAK53798)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 56896 MW; 4B3F95D0FB18DCF8 CRC64;
MAGGGGGSTS GEGPRELDQT PTWAVSTVCG VIILISIVLE LMIHKIGEVF TERRKKALYE
ALQKIKNELM VLGFISLLLT FGQNYIASLC VASRYGHAMS FCGPYDGPSG ESKKPKTTEH
LERRVLADAA PAQCKKGYVP LISLNALHQV HIFIFFLAVF HVIYSAITMM LGRAKIRGWK
VWEEEVINDH EMMNDPSRFR LTHETSFVRE HVNPWAKNRF SFYVMCFFRQ MLRSVRKSDY
LTMRHGFISV HLAPGMKFNF QKYIKRSLED DFKVVVGISP ELWAFVMLFL LFDVHGWYVT
AVITMIPPLL TLAIGTKLQA IISDMALEIQ ERHAVIQGMP LVNVSDRHFW FSRPALVLHI
IHFILFQNAF EITYFFWIWY EFGLRSCFHH HFALIIIRVA LGVGVQFLCS YITLPLYALV
TQMGSTMKRS VFDDQTSKAL KNWHKNAKKK SETPGQTQPP LPNLRPKTGG DIESASPANI
TASVDVKESD QSQSRDLLSG P
//
