ID MMPLC_MYCTU Reviewed; 1146 AA.
AC P9WJT7; L0T6X0; Q50585;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Probable transport protein MmpL12 {ECO:0000305};
GN Name=mmpL12; OrderedLocusNames=Rv1522c; ORFNames=MTCY19G5.06;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR EMBL; AL123456; CCP44286.1; -; Genomic_DNA.
DR PIR; B70723; B70723.
DR RefSeq; NP_216038.1; NC_000962.3.
DR RefSeq; WP_003898915.1; NZ_NVQJ01000004.1.
DR AlphaFoldDB; P9WJT7; -.
DR STRING; 83332.Rv1522c; -.
DR PaxDb; 83332-Rv1522c; -.
DR DNASU; 886445; -.
DR GeneID; 886445; -.
DR KEGG; mtu:Rv1522c; -.
DR TubercuList; Rv1522c; -.
DR eggNOG; COG1033; Bacteria.
DR eggNOG; COG1511; Bacteria.
DR eggNOG; COG2409; Bacteria.
DR InParanoid; P9WJT7; -.
DR OrthoDB; 2365435at2; -.
DR PhylomeDB; P9WJT7; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052572; P:response to host immune response; IMP:MTBBASE.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1146
FT /note="Probable transport protein MmpL12"
FT /id="PRO_0000103580"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 826..846
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 850..870
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 883..903
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 928..948
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 949..969
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1146 AA; 122430 MW; AC03075641C5CB09 CRC64;
MARHDEAKAG GLFDRIGNFV VRWPLIVIGC WIAVAAALTL LLPTLQAQAA KREQAPLPPG
APSMVLQKEM SAAFQEKIET SALLLVLLTN ENGLGPADEA VYRKLIENLR ADTQDKISVQ
DFLAVPEMKE LLASKDNKAW NLPITFAGDA ASPETQAAFK RVAAIVKQTV AGTSLTVHLS
GPIATVADLT ELGEKDVRII EIGTAVSVLI ILILVYRNLV TMLVPLATIG ASVVTAQGTL
SGLAEFGLAV NMQAIVFMSA VMIGAGTDYA VFLISRYHDY VRHGEKSDMA VKKALMSIGK
VITASAATVA VTFLAMVFTK LEVFSAVGPA IAVAITVSLL GAVTLLPAIL TLTGRRGWIK
PRRDLTSRMW RRSGVRIVRR STIHLVGSLI VLVALAGCTL LIRFNYDDLK TVPQHVESVK
GYEAMNRHFP MNAMTPMVLF IKSPRDLRTP GALADIEMMS REIAELPNIV MVRGLTRPNG
EPLKETKVSF QAGEVGGKLD EATTLLEEHG GELDQLTGGA HQLADALAQI RNEINGAVAS
SSGIVNTLQA MMDLMGGDKT IRQLENASQY VGRMRALGDN LSGTVTDAEQ IATWASPMVN
ALNSSPVCNS DPACRTSRAQ LAAIVQAQDD GLLRSIRALA VTLQQTQEYQ TLARTVSTLD
GQLKQVVSTL KAVDGLPTKL AQMQQGANAL ADGSAALAAG VQELVDQVKK MGSGLNEAAD
FLLGIKRDAD KPSMAGFNIP PQIFSRDEFK KGAQIFLSAD GHAARYFVQS ALNPATTEAM
DQVNDILRVA DSARPNTELE DATIGLAGVP TALRDIRDYY NSDMKFIVIA TIVIVFLILV
ILLRALVAPI YLIGSVLISY LSALGIGTLV FQLILGQEMH WSLPGLSFIL LVAIGADYNM
LLISRIRDES PHGIRIGVIR TVGSTGGVIT SAGLIFAASM FGLVGASINT MAQAGFTIGI
GIVLDTFLVR TVTVPALTTM IGRANWWPSE LGRDPSTPPT KADRWLRRVK GHRRKAPIPA
PKPPHTKVVR NTNGHASKAA TKSVPNGKPA DLAEGNGEYL IDHLRRHSLP LFGYAAMPAY
DVVDGVSKPN GDGAHIGKEP VDHLLGHSLP LFGLAGLPSY DRWDDTSIGE PAVGHAGSKP
DAKLST
//
