ID MNHA2_STAA8 Reviewed; 800 AA.
AC Q2G2U8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Putative antiporter subunit mnhA2;
DE AltName: Full=Mrp complex subunit A2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhA2;
GN Name=mnhA2; Synonyms=mrpA2; OrderedLocusNames=SAOUHSC_00625;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000305}.
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DR EMBL; CP000253; ABD29762.1; -; Genomic_DNA.
DR RefSeq; WP_000060776.1; NZ_LS483365.1.
DR RefSeq; YP_499187.1; NC_007795.1.
DR AlphaFoldDB; Q2G2U8; -.
DR SMR; Q2G2U8; -.
DR STRING; 93061.SAOUHSC_00625; -.
DR PaxDb; 1280-SAXN108_0688; -.
DR GeneID; 3920035; -.
DR KEGG; sao:SAOUHSC_00625; -.
DR PATRIC; fig|93061.5.peg.561; -.
DR eggNOG; COG1009; Bacteria.
DR HOGENOM; CLU_007100_2_1_9; -.
DR OrthoDB; 9807568at2; -.
DR PRO; PR:Q2G2U8; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..800
FT /note="Putative antiporter subunit mnhA2"
FT /id="PRO_0000372294"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..615
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 800 AA; 89687 MW; 92A69A7C860A06D7 CRC64;
MSLVYLLIAI LVIMAMILLM SKRRALAKYA GYIALVAPVI SSIYFLIQIP SVAKLQYLST
SIPWIKTLDI NLDLRLDGLS LMFSLIISLI GIAVFFYATQ YLSSRKDNLP RFYFYLTLFM
FSMIGIVLSD NTILMYIFWE LTSVSSFLLI SYWYNNGDSQ FGAIQSFMIT VFGGLALLVG
FIMLYIMTGT NNITEILGQA DHIKNHGLFI PMIFMFLLGA FTKSAQFPFH IWLPRAMAAP
TPVSAYLHSA TMVKAGIFLL LRFTPLLGLS NMYVYIVTFV GLITMLFGSI TALKQWDLKG
ILAYSTISQL GMIMAMVGIG GGYAQHQQDA IASIYVFVLF GALFHLMNHA IFKCALFMGV
GILDHEAGSR DIRILSGMRQ LFPKMNLVMT IAALSMAGVP FLNGFLSKEM FLDALTQTGQ
LSQFSLISMI AIVFVGVIAS VFTFTYALYM VKEVFWTKYD SKVFTKKNIH EPWLFSLPSL
ILMVLVPVIF FVPNIFGKGI IVLALRAVSG GNHQIDQLAP HVSQWHGFNI PLLLTIIIIL
LGSVLAIKVD WKKVFTGKIR QISVSKSYEM VYRHFEKFAT KRFKRVMQDR LNQYIIMTLG
IFMIIIGYGY IRIGLPKVHQ LHVSEFGALE IILAIVTVTI GISLIFIRQR LTMVILNGVI
GFVVTLFFIA MKAPDLALTQ LVVETITTIL FIVSFSRLPN VPRSNANKKR EIIKISVSLL
MALIVVSLIF ITQQTDGLSS ISDFYLKADK LTGGKNIVNA ILGDFRALDT LFEGLVLIIT
GLGIYTLLNY QDRRGQDERE
//
