ID MPC2_RAT Reviewed; 127 AA.
AC P38718;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=Mitochondrial pyruvate carrier 2;
DE AltName: Full=Brain protein 44;
DE AltName: Full=Protein 0-44;
GN Name=Mpc2; Synonyms=Brp44;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT), AND TISSUE
RP SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=3022128; DOI=10.1128/mcb.6.3.768-778.1986;
RA Tsou A.-P., Lai C., Danielson P., Noonan D.J., Sutcliffe J.G.;
RT "Structural characterization of a heterogeneous family of rat brain
RT mRNAs.";
RL Mol. Cell. Biol. 6:768-778(1986).
CC -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC {ECO:0000250|UniProtKB:O95563}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in);
CC Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000250|UniProtKB:O95563};
CC -!- SUBUNIT: Homodimer. Homooligomer. Forms heterodimers with MPC1 and
CC MPC1L. The heterodimer is the more stable and dominant form.
CC {ECO:0000250|UniProtKB:O95563}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95563}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P38718-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P38718-2; Sequence=VSP_006719;
CC -!- TISSUE SPECIFICITY: Liver, kidney, and brain.
CC {ECO:0000269|PubMed:3022128}.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M13095; AAA40791.1; -; Genomic_DNA.
DR EMBL; M13094; AAA40791.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001071111.1; NM_001077643.2. [P38718-1]
DR RefSeq; XP_006250188.1; XM_006250126.2. [P38718-2]
DR AlphaFoldDB; P38718; -.
DR SMR; P38718; -.
DR BioGRID; 1199117; 1.
DR STRING; 10116.ENSRNOP00000004206; -.
DR GuidetoPHARMACOLOGY; 3023; -.
DR iPTMnet; P38718; -.
DR PhosphoSitePlus; P38718; -.
DR jPOST; P38718; -.
DR PaxDb; 10116-ENSRNOP00000004206; -.
DR Ensembl; ENSRNOT00000004206.8; ENSRNOP00000004206.6; ENSRNOG00000003150.8. [P38718-1]
DR Ensembl; ENSRNOT00055029758; ENSRNOP00055023903; ENSRNOG00055017585. [P38718-1]
DR Ensembl; ENSRNOT00060016624; ENSRNOP00060012986; ENSRNOG00060009849. [P38718-1]
DR Ensembl; ENSRNOT00065033125; ENSRNOP00065026490; ENSRNOG00065019658. [P38718-1]
DR GeneID; 100359982; -.
DR KEGG; rno:100359982; -.
DR AGR; RGD:1563422; -.
DR CTD; 25874; -.
DR RGD; 1563422; Mpc2.
DR eggNOG; KOG1589; Eukaryota.
DR GeneTree; ENSGT00510000047120; -.
DR HOGENOM; CLU_099502_4_1_1; -.
DR InParanoid; P38718; -.
DR OMA; PQQFAIC; -.
DR OrthoDB; 590256at2759; -.
DR PhylomeDB; P38718; -.
DR PRO; PR:P38718; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000003150; Expressed in kidney and 20 other cell types or tissues.
DR Genevisible; P38718; RN.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; ISO:RGD.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; ISO:RGD.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; ISS:UniProtKB.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISO:RGD.
DR InterPro; IPR005336; MPC.
DR PANTHER; PTHR14154:SF2; MITOCHONDRIAL PYRUVATE CARRIER 2; 1.
DR PANTHER; PTHR14154; UPF0041 BRAIN PROTEIN 44-RELATED; 1.
DR Pfam; PF03650; MPC; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..127
FT /note="Mitochondrial pyruvate carrier 2"
FT /id="PRO_0000212796"
FT TOPO_DOM 2..40
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:O95563"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..72
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:O95563"
FT TRANSMEM 73..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..95
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:O95563"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..127
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:O95563"
FT MOD_RES 26
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9D023"
FT VAR_SEQ 117..127
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_006719"
SQ SEQUENCE 127 AA; 14258 MW; BE8AEC82CA4405A6 CRC64;
MAAAGARGLR ATYHRLMDKV ELLLPKKLRP LYNHPAGPRT VFFWAPIMKW GLVCAGLADM
ARPAEKLSTA QSTVLMATGF IWSRYSLVII PKNWSLFAVN FFVGSAGASQ LFRIWKYNQE
LKSKGIQ
//
