ID MPV17_BOVIN Reviewed; 176 AA.
AC Q2KIN6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Protein Mpv17;
GN Name=MPV17;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Non-selective channel that modulates the membrane potential
CC under normal conditions and oxidative stress, and is involved in
CC mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside
CC triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA)
CC maintenance (By similarity). May be involved in the regulation of
CC reactive oxygen species metabolism and the control of oxidative
CC phosphorylation (By similarity). {ECO:0000250|UniProtKB:P19258,
CC ECO:0000250|UniProtKB:P39210}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P39210}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P39210}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; BC112572; AAI12573.1; -; mRNA.
DR RefSeq; NP_001039394.1; NM_001045929.2.
DR RefSeq; XP_005212995.1; XM_005212938.3.
DR AlphaFoldDB; Q2KIN6; -.
DR STRING; 9913.ENSBTAP00000024316; -.
DR PaxDb; 9913-ENSBTAP00000024316; -.
DR Ensembl; ENSBTAT00000085989.1; ENSBTAP00000064043.1; ENSBTAG00000018269.5.
DR GeneID; 505763; -.
DR KEGG; bta:505763; -.
DR CTD; 4358; -.
DR VEuPathDB; HostDB:ENSBTAG00000018269; -.
DR VGNC; VGNC:50219; MPV17.
DR eggNOG; KOG1944; Eukaryota.
DR GeneTree; ENSGT00940000160891; -.
DR HOGENOM; CLU_049109_8_3_1; -.
DR InParanoid; Q2KIN6; -.
DR OMA; WYQSKLA; -.
DR TreeFam; TF324070; -.
DR Reactome; R-BTA-9033241; Peroxisomal protein import.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000018269; Expressed in caput epididymis and 102 other cell types or tissues.
DR ExpressionAtlas; Q2KIN6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0015267; F:channel activity; ISS:UniProtKB.
DR GO; GO:0034614; P:cellular response to reactive oxygen species; IBA:GO_Central.
DR GO; GO:1901858; P:regulation of mitochondrial DNA metabolic process; ISS:UniProtKB.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266; PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17; 1.
DR PANTHER; PTHR11266:SF17; PROTEIN MPV17; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..176
FT /note="Protein Mpv17"
FT /id="PRO_0000234398"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT SITE 92
FT /note="Determines ion selectivity"
FT /evidence="ECO:0000250|UniProtKB:P39210"
SQ SEQUENCE 176 AA; 19586 MW; 5F6467B75CC9BC78 CRC64;
MALWRAYQRA LTAHPWKVQV LTAGSLMGLG DVISQQLVER RGLQAHQAGR TLTMASLGCG
FVGPVVGGWY RVLDRLIPGT TKVDALKKML LDQGGFAPCF LGCFLPLVGT LNGLSAQDNW
AKLQRDFPDA LITNYYLWPA VQLANFYLVP LHYRLAVVQC VAVIWNSYLS WKAHRL
//
