ID MQO_BLOPB Reviewed; 515 AA.
AC Q492E3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=BPEN_548;
OS Blochmannia pennsylvanicus (strain BPEN).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; ant endosymbionts; Blochmannia.
OX NCBI_TaxID=291272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BPEN;
RX PubMed=16077009; DOI=10.1101/gr.3771305;
RA Degnan P.H., Lazarus A.B., Wernegreen J.J.;
RT "Genome sequence of Blochmannia pennsylvanicus indicates parallel
RT evolutionary trends among bacterial mutualists of insects.";
RL Genome Res. 15:1023-1033(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP000016; AAZ41158.1; -; Genomic_DNA.
DR RefSeq; WP_011283069.1; NC_007292.1.
DR AlphaFoldDB; Q492E3; -.
DR STRING; 291272.BPEN_548; -.
DR KEGG; bpn:BPEN_548; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_6; -.
DR OrthoDB; 9763983at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000007794; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR NCBIfam; TIGR01320; mal_quin_oxido; 1.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..515
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_0000325487"
SQ SEQUENCE 515 AA; 58085 MW; 0A3FD48D065944E1 CRC64;
MSNVAVINQQ HRLIKITSSA DIVLIGAGIM SATFGMFLTI LEPTWRIHIY ERLSQPAQES
SNVWNNAGTG HAAFCELNYT QYNNKNCSVD ISKAIAVNEA FEISRQFWAY LVEIKVLKYP
SSFINNVPHM SFVWGEENVC FLKKRFQALL NSVLFSGMVY SEDLQQIRQW TPLIIDGRNV
SQKIAATRME MGTDVNFGAL TQQLLNELKK NVNFKMYLQH DVVSVQNNND ATWDVHVIDR
RCKHKKCIRT NYVFIGAGGR SLNLLQTSGI PEVYGYAGFP VGGQFLVTKN PKIVEQHLAK
VYGKASVNAP PMSVPHIDTR ILNGEKILLF GPFATFSSKF LKYGSWLDLF HSLNKHNVIP
ILQAGIDNFD LIKYLISQLV MSNMNRIDEL REYYPTVNPS DWTLVTAGQR VQIIKRNSNR
RGILQFGTEV VNSGDGTLSA LLGASPGAST VVSIILQLLN TMFNNKINSD VWKNKLIDMI
PSYTKNLNGD LILVNKIRQY TCNALKLNYI EAIDR
//
