ID MSP10_CAEEL Reviewed; 127 AA.
AC P05634; P05635; Q27280;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 27-MAR-2024, entry version 144.
DE RecName: Full=Major sperm protein 10/36/56/76;
DE Short=MSP;
GN Name=msp-10; ORFNames=K07F5.2;
GN and
GN Name=msp-36; ORFNames=C04G2.4;
GN and
GN Name=msp-56; ORFNames=K07F5.3;
GN and
GN Name=msp-76; ORFNames=ZK1251.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (MSP-10 AND MSP-56).
RC STRAIN=Bristol N2;
RX PubMed=6325882; DOI=10.1128/mcb.4.3.529-537.1984;
RA Klass M.R., Kinsley S., Lopez L.C.;
RT "Isolation and characterization of a sperm-specific gene family in the
RT nematode Caenorhabditis elegans.";
RL Mol. Cell. Biol. 4:529-537(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (MSP-10; MSP-36; MSP-56 AND
RP MSP-76).
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Central component in molecular interactions underlying sperm
CC crawling. Forms an extensive filament system that extends from sperm
CC villipoda, along the leading edge of the pseudopod.
CC -!- SUBCELLULAR LOCATION: Cell projection, pseudopodium. Cytoplasm,
CC cytoskeleton.
CC -!- TISSUE SPECIFICITY: Sperm.
CC -!- MISCELLANEOUS: Around 30 MSP isoforms may exist in C.elegans.
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DR EMBL; K02617; AAA28115.1; -; mRNA.
DR EMBL; K02618; AAA28116.1; -; Genomic_DNA.
DR EMBL; Z70284; CAA94278.1; -; Genomic_DNA.
DR EMBL; Z70718; CAA94674.1; -; Genomic_DNA.
DR EMBL; Z70284; CAA94283.1; -; Genomic_DNA.
DR EMBL; Z68222; CAA92502.1; -; Genomic_DNA.
DR PIR; F88801; F88801.
DR RefSeq; NP_501722.1; NM_069321.5.
DR RefSeq; NP_501760.1; NM_069359.5.
DR RefSeq; NP_501762.1; NM_069361.5.
DR RefSeq; NP_501834.1; NM_069433.3.
DR AlphaFoldDB; P05634; -.
DR SMR; P05634; -.
DR BioGRID; 42934; 1.
DR IntAct; P05634; 1.
DR STRING; 6239.C04G2.4.1; -.
DR EPD; P05634; -.
DR PaxDb; 6239-C04G2-4; -.
DR PeptideAtlas; P05634; -.
DR EnsemblMetazoa; C04G2.4.1; C04G2.4.1; WBGene00003432.
DR EnsemblMetazoa; K07F5.2.1; K07F5.2.1; WBGene00003425.
DR EnsemblMetazoa; K07F5.3.1; K07F5.3.1; WBGene00003449.
DR EnsemblMetazoa; ZK1251.6.1; ZK1251.6.1; WBGene00003463.
DR GeneID; 177828; -.
DR GeneID; 177830; -.
DR KEGG; cel:CELE_K07F5.2; -.
DR KEGG; cel:CELE_K07F5.3; -.
DR UCSC; ZK1251.6; c. elegans.
DR AGR; WB:WBGene00003425; -.
DR AGR; WB:WBGene00003432; -.
DR AGR; WB:WBGene00003449; -.
DR AGR; WB:WBGene00003463; -.
DR WormBase; C04G2.4; CE03853; WBGene00003432; msp-36.
DR WormBase; K07F5.2; CE03853; WBGene00003425; msp-10.
DR WormBase; K07F5.3; CE03853; WBGene00003449; msp-56.
DR WormBase; ZK1251.6; CE03853; WBGene00003463; msp-76.
DR eggNOG; ENOG502RXF6; Eukaryota.
DR GeneTree; ENSGT00970000195833; -.
DR HOGENOM; CLU_120664_0_1_1; -.
DR InParanoid; P05634; -.
DR OrthoDB; 2871602at2759; -.
DR PhylomeDB; P05634; -.
DR PRO; PR:P05634; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003425; Expressed in adult organism and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR PANTHER; PTHR22920; MAJOR SPERM PROTEIN; 1.
DR PANTHER; PTHR22920:SF7; MSP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50202; MSP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..127
FT /note="Major sperm protein 10/36/56/76"
FT /id="PRO_0000213436"
FT DOMAIN 9..126
FT /note="MSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250"
FT CONFLICT 46
FT /note="I -> T (in Ref. 1; AAA28115/AAA28116)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="T -> A (in Ref. 1; AAA28116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 127 AA; 14236 MW; E5B96631BEBF1419 CRC64;
MAQSVPPGDI QTQPNAKIVF NAPYDDKHTY HIKVINSSAR RIGYGIKTTN MKRLGVDPPC
GVLDPKEAVL LAVSCDAFAF GQEDTNNDRI TVEWTNTPDG AAKQFRREWF QGDGMVRRKN
LPIEYNP
//
