ID MUTH_HAEIN Reviewed; 223 AA.
AC P44688;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=HI_0403;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
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DR EMBL; L42023; AAC22062.1; -; Genomic_DNA.
DR PIR; H64065; H64065.
DR RefSeq; NP_438565.1; NC_000907.1.
DR PDB; 2AOQ; X-ray; 2.20 A; A=1-223.
DR PDB; 2AOR; X-ray; 2.00 A; A/B=1-223.
DR PDBsum; 2AOQ; -.
DR PDBsum; 2AOR; -.
DR AlphaFoldDB; P44688; -.
DR SMR; P44688; -.
DR STRING; 71421.HI_0403; -.
DR EnsemblBacteria; AAC22062; AAC22062; HI_0403.
DR KEGG; hin:HI_0403; -.
DR PATRIC; fig|71421.8.peg.422; -.
DR eggNOG; COG3066; Bacteria.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OrthoDB; 5634909at2; -.
DR PhylomeDB; P44688; -.
DR BioCyc; HINF71421:G1GJ1-418-MONOMER; -.
DR EvolutionaryTrace; P44688; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH-like; 1.
DR Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR NCBIfam; TIGR02248; mutH_TIGR; 1.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase;
KW Nuclease; Reference proteome.
FT CHAIN 1..223
FT /note="DNA mismatch repair protein MutH"
FT /id="PRO_0000198669"
FT HELIX 6..16
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 21..27
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 42..51
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 59..61
FT /evidence="ECO:0007829|PDB:2AOR"
FT TURN 64..67
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 100..102
FT /evidence="ECO:0007829|PDB:2AOQ"
FT HELIX 104..109
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 110..118
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 125..127
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 140..158
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 162..164
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 171..177
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 179..181
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 186..189
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 195..198
FT /evidence="ECO:0007829|PDB:2AOR"
FT STRAND 201..205
FT /evidence="ECO:0007829|PDB:2AOR"
FT HELIX 207..218
FT /evidence="ECO:0007829|PDB:2AOR"
SQ SEQUENCE 223 AA; 24906 MW; 339A4EF9DA0E622A CRC64;
MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA LGATAGSKAE
QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW ENSHVRHKLS CVLWMPIEGS
RHIPLRERHI GAPIFWKPTA EQERQLKQDW EELMDLIVLG KLDQITARIG EVMQLRPKGA
NSRAVTKGIG KNGEIIDTLP LGFYLRKEFT AQILNAFLET KSL
//
