ID MUTH_PASMU Reviewed; 222 AA.
AC Q9CLY2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=PM1067;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
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DR EMBL; AE004439; AAK03151.1; -; Genomic_DNA.
DR RefSeq; WP_005751795.1; NC_002663.1.
DR AlphaFoldDB; Q9CLY2; -.
DR SMR; Q9CLY2; -.
DR STRING; 272843.PM1067; -.
DR EnsemblBacteria; AAK03151; AAK03151; PM1067.
DR KEGG; pmu:PM1067; -.
DR PATRIC; fig|272843.6.peg.1081; -.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OrthoDB; 5634909at2; -.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH-like; 1.
DR Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR NCBIfam; TIGR02248; mutH_TIGR; 1.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome.
FT CHAIN 1..222
FT /note="DNA mismatch repair protein MutH"
FT /id="PRO_0000198670"
SQ SEQUENCE 222 AA; 24762 MW; DC5EE92ED87FC977 CRC64;
MTPQTEQELL QRAQAIAGLR FAELAQSLHM PVPPDLKRDK GWVGMLIETA LGATAGSKAE
QDFAHLGIEL KTLPINAQGM PLETTFVSLA PLTQNVGVSW ENSHVRHKLS KVLWILVEGE
RQIPLSERRV GQPILWQPSA QQELRLKRDW EELMEYISLG KLEQINATLG EVLQLRPKGA
NSKALTRGIG KHGEMIDTLP LGFYLRKTFT AEILQQFLLG TG
//
