ID   MUTL_BRUA2              Reviewed;         623 AA.
AC   Q2YIH2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BAB2_0212;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM040265; CAJ12378.1; -; Genomic_DNA.
DR   RefSeq; WP_002966364.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YIH2; -.
DR   SMR; Q2YIH2; -.
DR   STRING; 359391.BAB2_0212; -.
DR   GeneID; 45125614; -.
DR   KEGG; bmf:BAB2_0212; -.
DR   PATRIC; fig|359391.11.peg.2162; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..623
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009997"
FT   REGION          353..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   623 AA;  66783 MW;  7CB97FEC4AE64BEF CRC64;
     MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG KTLLRVTDNG
     SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI GSVSKLTLKS RPQDADSGFE
     VCVTGGHLDG PRPTALNRGT IVEVRDLFYA TPARLKFMKT DRAEATAITD VVKRIGIAFP
     HIRFSLAGTD RTPFEMPATG TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI
     PSFNRGNALH QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV
     HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG FGAQQSAPRP
     ANSYSPASWR TAPPAPRSEW SPQTAHPAHR PLDLQAAPAL RENGQAVLGD VAVPAADARA
     SVAEAPVELM QKPLGAARAQ IHENYIVAQT EDSLVIVDQH AAHERLVYEA LKNALHARPI
     AGQMLLIPEI VDLPEEDAQR LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL
     IRDLADEIAE HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT
     CNHGRPTYIE LKLTDIERLF GRR
//