ID MUTL_GEOKA Reviewed; 630 AA.
AC Q5L0E4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GK1307;
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; BA000043; BAD75592.1; -; Genomic_DNA.
DR RefSeq; WP_011230806.1; NC_006510.1.
DR AlphaFoldDB; Q5L0E4; -.
DR SMR; Q5L0E4; -.
DR STRING; 235909.GK1307; -.
DR KEGG; gka:GK1307; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..630
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010017"
FT REGION 361..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 70066 MW; 92D939BE304B74C5 CRC64;
MGRIRKLDDL LANKIAAGEV VERPASVVKE LVENAIDAHS TVINIELEEA GMAKIRVIDN
GDGMEEDDCL LAFERHATSK IHDEHDLFRI RTLGFRGEAL PSIASVSEVE LTTGTGSGPG
TKLVLQGGAL VSRERAAGRK GTDITVSNLF FNTPARLKYM KTIHTELGHA ADVVNRLALA
HPDVSFRLRH QGKTLLATNG SGDVRHVLAA IYGAETARQM IPIEAESLDF TIRGYISPPD
VTRASRNYIS LVVNGRYVRS VPLMKAIEAG YHTLLPIGRY PIVFLSIEMD PVLVDVNVHP
AKLEVRFSKE AELNELVTDA IRQAFRKRTL IPSVSADSKM AKPKAEQAAW TFTHRVREPS
VLSSDIGGGE DATAPLAPLT GDAPAERPSA AVQTDECGIL DEHGPAFERK QEEEVGEERC
SPRLPTDGQA EDKAAADRLP PLYPIGQLHG TYILAENEHG LYMIDQHAAQ ERINYEYFRE
KLGEATKEVQ ELLVPLMFEY PADEYERIAA CRDELARCGV FLEPFGPRAF LVRSHPTWFP
KGREREIIEE MIEQVLAAKT VDIKQLREQA AILMSCKRAI KANQHLRQDE LFALLEALRQ
TTDPFTCPHG RPIIVHFSTY EIEKLFKRVM
//
