ID MUTL_GEOTN Reviewed; 645 AA.
AC A4IMI1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=GTNG_1161;
OS Geobacillus thermodenitrificans (strain NG80-2).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=420246;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NG80-2;
RX PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA Han W., Peng X., Liu R., Wang L.;
RT "Genome and proteome of long-chain alkane degrading Geobacillus
RT thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000557; ABO66535.1; -; Genomic_DNA.
DR RefSeq; WP_011887175.1; NC_009328.1.
DR AlphaFoldDB; A4IMI1; -.
DR SMR; A4IMI1; -.
DR KEGG; gtn:GTNG_1161; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR Proteomes; UP000001578; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..645
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010019"
SQ SEQUENCE 645 AA; 71546 MW; F3FBC286F9495F9D CRC64;
MGRIHKLDDQ LANKIAAGEV VERPASVVKE LVENAIDAHS TAVEIELEEA GMTKIRVIDN
GDGMEEEDCL LAFERHATSK IQDEHDLFRI RTLGFRGEAL PSIASVSEVE LVTSTGSGPG
TKLVLKGGAL VARERAAGRK GTDITVSNLF FNTPARLKYM KTIHTELGHA ADVVNRLALA
HPDVSFRLRH HGKTLLATNG SGDVRHVLAA IYGMETAKQM IPIEAESLDF TVRGYISLPE
VTRASRNYMS LIVNGRYVRN IPLMKAIEAG YHTLLPIGRY PIVFLAIEMD PVLVDVNVHP
AKLEVRFSKE AELNELITAT IRQAFRQRTL IPSVSADSKT VKAKAEQASW TFAHRVHEPP
AQPDGKAEGT SDVTAAASLA SEGSLSPLPA AAQADAPAVS EEAEASVFSE RRTGVVNDLP
AAELKRDAEV EEEPTEACLP ADEQAEEKRA VDRLPPLYPI GQLHGTYILA ENEHGLYMID
QHAAQERINY EYFREKLGEV TNEVQELLVP LTFEYPADEY ERIAACRDEL ARCGVFLEPF
GPRAFLVRSH PVWFPKGKEK EIIEEMIEHV LTAKTVDIKQ LREQAAIVMS CKRAIKANQH
LRTDEIFALL ETLRQTTDPF TCPHGRPIIV HFSTYEIEKL FKRVM
//
