ID MUTL_HAEIN Reviewed; 629 AA.
AC P44494;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=DNA mismatch repair protein MutL;
GN Name=mutL; OrderedLocusNames=HI_0067;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC21745.1; -; Genomic_DNA.
DR PIR; E64046; E64046.
DR RefSeq; NP_438240.1; NC_000907.1.
DR AlphaFoldDB; P44494; -.
DR SMR; P44494; -.
DR STRING; 71421.HI_0067; -.
DR EnsemblBacteria; AAC21745; AAC21745; HI_0067.
DR KEGG; hin:HI_0067; -.
DR PATRIC; fig|71421.8.peg.68; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_5_1_6; -.
DR OrthoDB; 9763467at2; -.
DR PhylomeDB; P44494; -.
DR BioCyc; HINF71421:G1GJ1-68-MONOMER; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..629
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177947"
SQ SEQUENCE 629 AA; 71623 MW; 0ADC240FD94D1556 CRC64;
MPIKILSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAN KIQIDIENGG ANLIRIRDNG
CGIPKEELSL ALARHATSKI ADLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTEEQTEA
WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFSH IDEVIRRIAL
TKFNTAFTLT HNGKIIRQYR PAEAINQQLK RVAAICGDDF VKNALRIEWK HDDLHLSGWV
ATPNFSRTQN DLSYCYINGR MVRDKVISHA IRQAYAQYLP TDAYPAFVLF IDLNPHDVDV
NVHPTKHEVR FHQQRLIHDF IYEGISHALN NQEQINWHTD QSAVENHEEN TVREPQPNYS
IRPNRATAGQ NSFAPQYHEK PQQNQPHFSN TPMFPNHVST GYRDYRSDAP SKTEQRLYAE
LLRTLPPTAQ KDISDTAQQN ISDTAKIIST EIIECSSHLR ALSLIENRAL LLQQNQDFFL
LSLEKLQRLQ WQLALKQIQI EQQALLIPIV FRLTESQFQA WQQYSDDFKK IGFEFIENQA
QLRLTLNKVP SALRTQNLQK CVMAMLTRDE NSSSFLTALC AQLECKTFNA LADALNLLSE
TERLLTQTNR TAFTQLLKPV NWQPLLDEI
//
