ID MUTL_PSEAE Reviewed; 633 AA.
AC Q9HUL8;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PA4946;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; AE004091; AAG08331.1; -; Genomic_DNA.
DR PIR; F83028; F83028.
DR RefSeq; NP_253633.1; NC_002516.2.
DR RefSeq; WP_003106411.1; NZ_QZGE01000002.1.
DR AlphaFoldDB; Q9HUL8; -.
DR SMR; Q9HUL8; -.
DR STRING; 208964.PA4946; -.
DR PaxDb; 208964-PA4946; -.
DR GeneID; 878468; -.
DR KEGG; pae:PA4946; -.
DR PATRIC; fig|208964.12.peg.5179; -.
DR PseudoCAP; PA4946; -.
DR HOGENOM; CLU_004131_4_2_6; -.
DR InParanoid; Q9HUL8; -.
DR OrthoDB; 9763467at2; -.
DR PhylomeDB; Q9HUL8; -.
DR BioCyc; PAER208964:G1FZ6-5062-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..633
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177958"
FT REGION 337..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 69748 MW; 3FD58AF0A721FE2D CRC64;
MSEAPRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD AGSRRIDVEV EQGGIKLLRV
RDDGRGIPAD DLPLALARHA TSKIRELEDL ERVMSLGFRG EALASISSVA RLTMTSRTAD
AGEAWQVETE GRDMQPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLRAEKT EFDHLQEVIK
RLALARFDVA FHLRHNGKTI FALHEARDEL ARARRVGAVC GQAFLEQALP IEVERNGLHL
WGWVGLPTFS RSQPDLQYFY VNGRMVRDKL VAHAVRQAYR DVLYNGRHPT FVLFFEVDPA
VVDVNVHPTK HEVRFRDSRM VHDFLYGTLH RALGEVRPDD QLAPPGATSL TEPRPTGAAA
GEFGPQGEMR LAESVLESPA ARVGWSGGSS ASGGSSGYSA YTRPEAPPSL AEAGGAYKAY
FAPLPAGEAP AALPESAQDI PPLGYALAQL KGIYILAENA HGLVLVDMHA AHERITYERL
KVAMASEGLR GQPLLVPESI AVSEREADCA EEHSSWFQRL GFELQRLGPE SLAIRQIPAL
LKQAEATQLV RDVIADLLEY GTSDRIQAHL NELLGTMACH GAVRANRRLT LPEMNALLRD
MEITERSGQC NHGRPTWTQL GLDELDKLFL RGR
//
