ID MUTS_AROAE Reviewed; 879 AA.
AC Q5NYP9;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AZOSEA36900;
GN ORFNames=ebA6453;
OS Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales;
OC Rhodocyclaceae; Aromatoleum.
OX NCBI_TaxID=76114;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EbN1;
RX PubMed=15551059; DOI=10.1007/s00203-004-0742-9;
RA Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F.,
RA Reinhardt R.;
RT "The genome sequence of an anaerobic aromatic-degrading denitrifying
RT bacterium, strain EbN1.";
RL Arch. Microbiol. 183:27-36(2005).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CR555306; CAI09815.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5NYP9; -.
DR SMR; Q5NYP9; -.
DR STRING; 76114.ebA6453; -.
DR KEGG; eba:ebA6453; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_4; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000006552; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..879
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224344"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 879 AA; 95162 MW; 04D82C4FEF7A8509 CRC64;
MGMSEIAKAA QKDKAIGGAD RDSHTPMMQQ YLRIKAQHPD TLLFYRMGDF YELFFDDAEK
AARLLDITLT TRGQSAGTPI RMAGVPFHAV EQYLARLVKL GESVVIAEQV GEPGATKGPM
ERAVSRIVTP GTLTDAALLD DRIDSLLLAA TLHRGVLGLA WLNLANGDLR VMECPAEQLQ
AQFERLRPAE VLVPDGLALP LVESLSPVLR RLADWQFDAG NGERLLTAHF GTRDLAGFDA
EGLPVALAAA AALFEYARST QRQSLEHVTG LRVEREAEYL RLDAATRRNL ELTETLRGEA
SPTLFSLLDS CITSMGSRWL RHALHHPLRD RGVAAQRHGA VGELAGSDAG APADIGDARM
LGAVRAALRG VADVDRITAR IALRSARPRD LAALSDSLAR LPQLHAALGT PQAPLLCDLL
AAIAVPDNAL DLLVRAVAAE PAAAVRDGGV IAPGFDAELD ELRGIQSNCG EFLLALEVRE
RERSGIATLK VEFNKVHGFY IEVSHANTGK VPDDYRRRQT LKNAERYITP ELKAFEDKAL
SAQERALARE KLLYEALLEA LAAHIPALQR IARALACLDG LGAFAEAAVR HSYVCPQFSA
QPGVDIIGGR HPVVERQVED FISNNCRLAP TRRMLLITGP NMGGKSTFMR QVALIALLAH
VGAFVPARSA RLGPLDAIFT RIGASDDLAS GRSTFMVEMT EASAILHGAT EQSLVLMDEI
GRGTSTFDGL ALAFAIARHL LEKNRCLTLF ATHYFELTRL NGDYPECANV HLDAVEHAHR
IVFLHAVEDG PASQSYGIEV AALAGIPGSV VREAKRRLRA LENREVGNGP QADLFAALPD
REPATPSHPA LTALAELDPD TLSPREALER LYALKRMTA
//
