ID MUTS_BACFN Reviewed; 879 AA.
AC Q5L7B7;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BF4369;
OS Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS / NCTC 9343 / Onslow).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=272559;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow;
RX PubMed=15746427; DOI=10.1126/science.1107008;
RA Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA Barrell B.G., Parkhill J.;
RT "Extensive DNA inversions in the B. fragilis genome control variable gene
RT expression.";
RL Science 307:1463-1465(2005).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CR626927; CAH10035.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5L7B7; -.
DR SMR; Q5L7B7; -.
DR PaxDb; 272559-BF9343_4254; -.
DR KEGG; bfs:BF9343_4254; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR Proteomes; UP000006731; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..879
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224350"
FT BINDING 625..632
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 879 AA; 99288 MW; F51164CBA7BB7E84 CRC64;
MNLKRRLSVS NDIELTPMMK QFLDLKAKHP DAVMLFRCGD FYETYSTDAI IAAEILGITL
TKRANGKGKT VEMAGFPHHA LDTYLPKLIR AGKRVAICDQ LEDPKTTKKL VKRGITELVT
PGVSINDNVL NYKENNFLAA VHFGKSACGI AFLDISTGEF LTAEGPFDYV DKLLNNFAPK
EILFERGKRG MFEGNFGSKF FTFELDDWVF TESSSREKLL KHFETKNLKG FGVEHLKNGI
IASGAILQYL DMTEHTQVGH ITSLARIEED KYVRLDKFTV RSLELIGSMN DGGSSLLHVI
DKTISPMGAR LLKRWMVFPL KDEKPINDRL NVVEYFFRKP DFRELIEDEL HRIGDLERII
SKVAVGRVSP REVVQLKVAL QAIEPIKEAC QQADNPSLNR IGEQLNLCIS IRDRIEKEIN
NDPPLLINKG GVIKDGVDTE LDELRQIAYS GKDYLLKIQQ RESELTGIPS LKIAYNSVFG
YYIEVRNVHK DKVPQEWIRK QTLVNAERYI TQELKEYEEK ILGAEDKILV LETRLYTELV
QALSEFIPAI QINANQIARI DCLLSFANVA KENNYIRPVI EDNDVLDIRQ GRHPVIEKQL
PIGEKYIAND VLLDNATQQV IIITGPNMAG KSALLRQTAL ITLLAQIGSF VPAESAHIGL
VDKIFTRVGA SDNISVGEST FMVEMNEASD ILNNISSRSL VLFDELGRGT STYDGISIAW
AIVEYIHEHP KAKARTLFAT HYHELNEMEK SFKRIKNYNV SVKEVDNKVI FLRKLERGGS
EHSFGIHVAK MAGMPKSIVK RANEILKQLE SDNRQQGISG KPLAEVSENR GGMQLSFFQL
DDPILCQIRD EILHLDVNNL TPIEALNKLN DIKKIVRGK
//
