ID MUTS_BACP2 Reviewed; 858 AA.
AC A8FDH3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BPUM_1608;
OS Bacillus pumilus (strain SAFR-032).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=315750;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAFR-032;
RX PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA Weinstock G.M.;
RT "Paradoxical DNA repair and peroxide resistance gene conservation in
RT Bacillus pumilus SAFR-032.";
RL PLoS ONE 2:E928-E928(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000813; ABV62290.1; -; Genomic_DNA.
DR RefSeq; WP_012010027.1; NZ_VEIC01000002.1.
DR AlphaFoldDB; A8FDH3; -.
DR SMR; A8FDH3; -.
DR STRING; 315750.BPUM_1608; -.
DR KEGG; bpu:BPUM_1608; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000001355; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..858
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000057633"
FT BINDING 600..607
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 858 AA; 97901 MW; 255280C920AEF02B CRC64;
MASYTPMIQQ YLNIKAEYQD AFLFFRLGDF YEMFFDDAKE ASQELEITLT SRDGGTIPMC
GVPYHSASAY IEQLISKGYK VAICEQVEDP KTAKGVVKRE VVQLITPGTV MEGKGLSENE
NNFIASVTKF ENGYGLALSD LSTGENMAAF IDRLDEVVSE IYSVGAKEIV VSKHLDEETV
KTLKERCQAT ISYEDSDELI DEAERLVSRL SEQLRSTFLT LYAYLRRTQK RSLDHLQQVQ
VFELEQTMKI DLYSKRNLEL TETIRSKSKK GSLLWLLDET KTAMGGRLLK QWIDRPLIRL
SHIKERQEMV QILMDHFFER EDLRERLKQV YDLERLAGRV AFGNVNARDL IQLKESLKQV
PAIKELVHSL PEEMAKSRAN DIDLCDDLLN LLEDALYENP PMTLKEGNLI KDGYNAKLDE
YRDASRNGKD WIARLEQQER EYTGIRSLKV GFNKVFGYYI EVTRANTHLL EEGRYERKQT
LANAERYITP ELKEKEALIL EAESNISELE YELFAALREQ VKVYIPRLQL LAKQMSELDA
LQCFATVSEK RRYIRPEFSE DEVDVIDGRH PVVEKVMDHQ EYVPNDCHMG NGRQTLLITG
PNMSGKSTYM RQMALISILA QIGCFVPASK ATLPIFDQIF TRIGAADDLI SGQSTFMVEM
LEAKNAMVHA TKNSLILFDE IGRGTSTYDG MALAQAIIEF VHDHVGAKTL FSTHYHELTV
LESQLSELKN VHVRAEEHEG TVVFLHQIKE GAADKSYGIH VAQLAELPDA IIDRAQTILT
ELESGSHEVT PHVSAAPKTE KAEEKQQLSF FEVEEKPQTK PVLKQKDQAV IEELKSFNLM
DMTPLEAMTK LYELQKKL
//
