ID MUTS_CAUVC Reviewed; 903 AA.
AC Q9AC54;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CC_0012;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AE005673; AAK22000.1; -; Genomic_DNA.
DR PIR; D87250; D87250.
DR RefSeq; NP_418832.1; NC_002696.2.
DR RefSeq; WP_010917902.1; NC_002696.2.
DR AlphaFoldDB; Q9AC54; -.
DR SMR; Q9AC54; -.
DR STRING; 190650.CC_0012; -.
DR EnsemblBacteria; AAK22000; AAK22000; CC_0012.
DR KEGG; ccr:CC_0012; -.
DR PATRIC; fig|190650.5.peg.13; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR BioCyc; CAULO:CC0012-MONOMER; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..903
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115082"
FT BINDING 655..662
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 903 AA; 96008 MW; C98D16803C703987 CRC64;
MNAHATPTPA HEIDPTGATP VMAQFFEMKA RQPDALIFFR MGDFYELFFD DAYKAAAALG
ISQTFRGTHN GQPIPMAGVP QHAAEAYLSK LIRLGFKVAV CEQMEDPAEA KKRGSKAVVR
RDIVRVVTPG TLTEDGLLDA RGANRLAAVA LRAGQAAVAS VELSTGEVEV LAVAKEGVAP
ILAALAPSET LVADRLLSDD SLSQTLRICG GLVQPMPSAL SEPQASETRV KRLYGVETLD
GFGGLSPAEI GALGLIAAHL EMTQAGRLPA LRAPRRAADA DVMAIDPATR SSLEIDRTQS
GDRNGSLLAA IDRTVTAGGA RMLASRLARP LLDVAAIDQR LDAVEWFVEH RQLRQRLREV
LKGAGDMARA LSRLALGRGG PRDLGCIRDT LKVGERLAGM AGGAPDPLSP PPFELEHAFK
ALTPALHEGL SQFLTTLEHG LGPDLPALAR DGGFVAAGVR PELDQARGLR DDSRKVIAAL
ESQLALESGV PLKIRHNGVL GYFVEATAGK ADPLFQPPLN ATFIHRQTLA NQVRFTTVEL
ADLDARIAQA AERALAMEVA AFEDWREQAR LLADAIQIAS EALARIDVAS SLAEWAEDAG
AVRPVVDASY AFDAKAARHP VVEAAVKRAG EPYTPNDCRL DASGETAARL SIVTGPNMAG
KSTFLRQNAL LAILAQSGCY VPAASFRLGV VDRLFSRVGA GDDLARGRST FMMEMVETAS
ILTQAGPRSL VILDEIGRGT ATYDGLAIAW ACAEALHDTN RCRALFATHY HELATLETRM
AFVSNLSLRA KEWNGDLVFL HEAAPGPADR SYGVQVAKLA GVPAPVVVRA REVLDRLESK
DQSPAKLDDL PLFAVSQAVA VTSAPAKAAP SAVETSLADL DVDGMSPREA LEALYRLKGL
LTA
//
