ID MUTS_DECAR Reviewed; 860 AA.
AC Q47DJ8;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Daro_2347;
OS Dechloromonas aromatica (strain RCB).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Azonexaceae;
OC Dechloromonas.
OX NCBI_TaxID=159087;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCB;
RX PubMed=19650930; DOI=10.1186/1471-2164-10-351;
RA Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G.,
RA Lapidus A.;
RT "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB:
RT indications of a surprisingly complex life-style and cryptic anaerobic
RT pathways for aromatic degradation.";
RL BMC Genomics 10:351-351(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000089; AAZ47083.1; -; Genomic_DNA.
DR AlphaFoldDB; Q47DJ8; -.
DR SMR; Q47DJ8; -.
DR STRING; 159087.Daro_2347; -.
DR KEGG; dar:Daro_2347; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_4; -.
DR OrthoDB; 9802448at2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..860
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224364"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 860 AA; 94565 MW; C49A830E543D33F9 CRC64;
MVKDKAPDLS KHTPMMRQYL ALKANHPNTL LFYRMGDFYE LFHEDAEKAA RLLDITLTTR
GQSAGVPIKM CGIPFHSLEP YLARLVKLGE SAVICEQIGD PATSKGPVER AVARIVTPGT
LTDAALIDDK QDLWLLAVTT HRNTAGIARL NLASGEFILI EVPTEQIPAT LERIRPAEIL
YPESWTPNFG VDVARTRQPD WYFEFDSARR LLCDQFEVAS LAGFGAEGLK PAIAAAGALL
QYAQATQSGK LPHLRGLTVE IEGAYLGLDL ATRRNLELTE TLRGQPSPTL FSLLDNCVTS
MGSRLLRHTL HHPLRARDIP AARHGAVEAL LEDYGRLGNE VRKALRGIAD IERIAGRVAL
RNARPRDLAS LRESVARLEG LRAPLSDSPA PLIAQLFTEL ETPYPALELL VRAIAAEPGA
QVRDGGVIAP GYDPDLDELR SLNDNCGAFL VDMEARERER SGIASLKVEY NKVHGFYIEV
THANVDKIPD DYRRRQTLKN AERYITPELK AFEDKALSAQ ERSLAREKLL YEAILDALLP
VVPTLQTIAR AIAQLDLLAG FAESALKRNW CKPEFAAETQ LSITGGRHPV VEGELTNQAE
TFIANDCLLA ENRRLLLITG PNMGGKSTYM RQVALIALLA HIGCYVPADR CVLGPLDRIF
TRIGASDDLA SGRSTFMVEM TEAAAILHHA TNQSLVLMDE IGRGTSTFDG MALAFAILRH
LIEKNQSLTL FATHYFELTR LSHEYSELAN VHLGAVEHND RIVFMHAVEE GPANQSYGIQ
VAALAGIPTA VVRAARKQLR EFEQRAAVDP LQPDLFAQGA PEPAEPEPHP VVEQLAAIDP
DSLTPREALD ALYALKGLLR
//
