ID MUTS_DESVH Reviewed; 905 AA.
AC P61666;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=DVU_1649;
OS Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS B-1760 / Hildenborough).
OC Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC Desulfovibrionaceae; Nitratidesulfovibrio.
OX NCBI_TaxID=882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX PubMed=15077118; DOI=10.1038/nbt959;
RA Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA Wall J.D., Voordouw G., Fraser C.M.;
RT "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT Desulfovibrio vulgaris Hildenborough.";
RL Nat. Biotechnol. 22:554-559(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AE017285; AAS96126.1; -; Genomic_DNA.
DR RefSeq; WP_010938938.1; NC_002937.3.
DR RefSeq; YP_010867.1; NC_002937.3.
DR AlphaFoldDB; P61666; -.
DR SMR; P61666; -.
DR IntAct; P61666; 1.
DR STRING; 882.DVU_1649; -.
DR PaxDb; 882-DVU_1649; -.
DR EnsemblBacteria; AAS96126; AAS96126; DVU_1649.
DR KEGG; dvu:DVU_1649; -.
DR PATRIC; fig|882.5.peg.1523; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_7; -.
DR OrthoDB; 9802448at2; -.
DR PhylomeDB; P61666; -.
DR Proteomes; UP000002194; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..905
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115093"
FT REGION 389..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 638..645
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 905 AA; 101578 MW; 7C6CB2C69308C9C2 CRC64;
MTNPSPKLTP MFEQYLRIKE DYPDALLFYR MGDFYELFFD DAETTARELQ IALTCRNPNA
ELKAPMCGVP YHAVEGYISQ LLDKGYRVAI CEQIEDPKEA KGLVKRAVTR VLTPGTVIDD
ANLDAKEHNY LGALFWNQDA EAGAFAWVDV STGEWSGLYS RKLAELWQWA QKMAPRELLL
PEGVDTPAMA TLGTTQTVRV PARSHFDLKS GTERVMRAQG VADLGSLGLE GKPELVRACA
ALLAYLAQTQ KQELSHLAPF KPLNLGRHLI IDEVTERNLE LFHRLDGRKG PGTLWHILDR
TLTPMGGRLL EERMHHPWRE ASPIRETQQV VEWLFQDDVR REALRTALDL VYDLERLSTR
IFLNRATPKD FIALRQSLSA LPAVRATLER PANPEGTYPT DAETSGDTLP KPLSDMLSAW
DDLADYADLL RRALTDNPPH LVTEGGLFRP GFDPDLDELL DLAEHGEARL QELLAEEQTV
SGLPKLKLGY NRVFGYFFEL SRAGADSVPE HFVRRQTLAN AERFTTERLK ELEEKLVSAT
DRRKTLEYRL FQSLRDTVAE ARPRVLFMAD MLAHLDFWQS LADVARRNGW VRPDVHTGHD
IVIREGRHPV VEAMQGSASF VPNDLRMDEK RRLLLITGPN MAGKSTVLRQ TAIICLLAQM
GAFVPAREAS IGIADRIFSR VGASDNLAQG QSTFMVEMME TARILRQASK RSLVILDEIG
RGTSTFDGMA LAWAVVEELT RRAGGGIRTL FATHYHEITS LEGRIPGVHN MNIAIREWNG
DIVFLRRLVP GPADKSYGIE VARLAGVPHS VVQRARELLA DLERTRDAAR GTNSAPSRQT
LPGLDLPSKQ EQVDTIVAPP PCSGVEHPLL VALRDIDTDD MTPLEALKRI TEWKQLWGTT
REDRS
//
