ID MUTS_LEGPH Reviewed; 846 AA.
AC Q5ZUJ3;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 24-JAN-2024, entry version 107.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lpg1805;
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAU27884.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE017354; AAU27884.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_014844166.1; NC_002942.5.
DR RefSeq; YP_095831.1; NC_002942.5.
DR AlphaFoldDB; Q5ZUJ3; -.
DR SMR; Q5ZUJ3; -.
DR STRING; 272624.lpg1805; -.
DR PaxDb; 272624-lpg1805; -.
DR GeneID; 66490937; -.
DR KEGG; lpn:lpg1805; -.
DR PATRIC; fig|272624.6.peg.1893; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..846
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224381"
FT BINDING 610..617
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 846 AA; 94775 MW; 0EFC9EF6E206EC62 CRC64;
MASSHTPMMQ QYLRIKTDYP DMLLFYRMGD FYELFFDDAK RASQLLDLTL THRGQSADKP
IPMAGVPYHA VENYLARLLK KGESVAICEQ IGDPATSKGP VERQVTRIIT PGTVTDEALL
DARKDNILLA IHTQKQKIGI AWVDLGGGRF HLQELTEEHQ LNAELVRLQP AELLCKESTP
LPSFCSNFAV KFRPGWEFDA SNAHKLLCEQ FSVTDLSAFG EQNYPTALIA AGALLAYLKT
TQKQSLPHLT TLTLEQSEDY LQLDASTQKH LELFENIHGG GEHCLLSILD KTACAMGSRL
LKRWLGKPLK QHAIIQTRQQ AIKEIIFLQQ DVSLHQLIKQ CADVERIVSR IALKSARPRD
LVSLLQTLTL LPAIHDELQE NKSLLINEIK KEISPLPLLQ QLLETAIIDN PPMLIRDGGV
IAPGFDEELD ELRNLSSNAH ETLVKLEQEE KNRTGLSTLK LGYNSVQGFY IELSKAQAQN
APPHFHRKQT LKNVERYITP ELKLFEDKVL SAQSKALARE KWLYDNLLEE IQQYIPELSD
LAKSLAQLDV LVTLAERAQS LNWNCPNLVP ESGIMIQAGR HPVIEPLLQE RFIANDLELK
PNQNMLLITG PNMGGKSTYM RQTALIVLLA HIGSFVPADK VTLGPLDRIF TRIGASDDLS
SGRSTFMVEM TETAQILRQA TSQSLVLIDE IGRGTSTYDG MALAYASCAF LASTIKAYTL
FSTHYLELTE LPKEFSCIRN VHLQASIKTG QIVFLYRVEE GCANRSYGLE VAELAGIPKE
VLKLAHEHLN QIQDTQSILV QTQIIKPPTS PVLTELKKID PDRLTAKEAL DLIYKLKHLE
CAESIN
//
