ID MUTS_METFK Reviewed; 884 AA.
AC Q1H2P1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS1 {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mfla_0834;
GN and
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Mfla_0978;
OS Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylobacillus.
OX NCBI_TaxID=265072;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT / ATCC 51484 / DSM 6875;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT "Complete sequence of Methylobacillus flagellatus KT.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000284; ABE49102.1; -; Genomic_DNA.
DR EMBL; CP000284; ABE49246.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1H2P1; -.
DR SMR; Q1H2P1; -.
DR STRING; 265072.Mfla_0834; -.
DR KEGG; mfa:Mfla_0834; -.
DR KEGG; mfa:Mfla_0978; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_1_4; -.
DR Proteomes; UP000002440; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..884
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335181"
FT BINDING 643..650
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 884 AA; 97850 MW; 9F71C3A2A58904F8 CRC64;
MHGEHDRGGV IIKVCDDVLA LAGKHERAIN LTKLDNTLEQ HTPMMRQYLG IKAQYPDMLV
FYRMGDFYEL FHDDAEKASR LLGITLTKRG SSNGEPIRMA GVPYHAAEQY LAKLAKLGEA
VAICEQVGDP AKSKGPVERQ VTRILTPGTL TDAALLDDTR DNLLLAIAHG EGVLGLARIN
LASGRFILSE ITPGLLAQEL ERISPAEILY PDDFYHMALE QVKCPKKRLA PWQFDLDSSI
QTLTKQFSTY DLDGFGCAHM LAAIMAAGAL LDYVKHTQRT SLPHIQSLMV EQGSQFIQLD
AATRRNLEID QTLRGESSPT LYSLLNTTVT AMGARLLRSW LHHPLQHQAD IQARLQAVKV
LQAQYDGLRP LLRNVGDIER MAARVALKTA RPRDLSGLRD SLQQLPALQR VLRPEDSALL
HSLQQQLDVP QAALDMLIAA IKDEPAAVLR EGGVIADGFD AELDELRAIQ SNCGEFLLQF
EAQERERSGI SNLKVEYNSV HGFYIEISRA QSENVPAEYR RRQTLKNVER YITPELKTFE
DKVLSANERA LAREKFLFDE LLGNLQPALA AWQRNAEAVA QLDVLATFAE RADVLKYVAP
QFSSEAGLDI VDGRHPVVEQ LAQPFIANSV SLSPYRQLLL ITGPNMGGKS TYMRQTALIV
LLAHCGCFVP AKSARIGPID RIFTRIGASD DLAGGRSTFM VEMTETANIL HNATERSLVL
LDEIGRGTST FDGLSLAWAV ARQLLEKNRS YTLFATHYFE LTRISEEFKH AANVHLDAVE
HGDGIVFLHN VEEGPASQSY GLQVAQLAGI PRTVVNAAKR KLVQLEQSQV MQQSLAGQGD
MFVAANVEPE PATHPVVSEL ESIDPDSLTP RQALDVLYKL KKLI
//
