ID MUTS_NITHX Reviewed; 907 AA.
AC Q1QQJ4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Nham_0614;
OS Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Nitrobacter.
OX NCBI_TaxID=323097;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10229 / NCIMB 13809 / X14;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Ward B., Arp D., Klotz M., Stein L.,
RA O'Mullan G., Starkenburg S., Sayavedra L., Poret-Peterson A.T.,
RA Gentry M.E., Bruce D., Richardson P.;
RT "Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000319; ABE61503.1; -; Genomic_DNA.
DR RefSeq; WP_011509207.1; NC_007964.1.
DR AlphaFoldDB; Q1QQJ4; -.
DR SMR; Q1QQJ4; -.
DR STRING; 323097.Nham_0614; -.
DR KEGG; nha:Nham_0614; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000001953; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..907
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335185"
FT BINDING 656..663
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 907 AA; 97501 MW; 55299C6EBA57E416 CRC64;
MTIQPAVPTS PTNAAPEAAR VTPMMEQYLE IKAANPGLLL FYRMGDFYEL FFEDAEIASC
TLGITLTKRG KHQGADIPMC GVPVERSDDY LHRLIAAGHR VAVCEQMEDP AAARRRGNKS
VVRRDVVRLI TPGTLTEDTL LDARANNYLL ALARARASSG GNRIALAWID ISTAEFIVTE
CSTGELAATL ARINPNEVIV SDALYGDPDM AALLRELPSV TPLTRDVFDG ATAERRLCDY
FAVATMDGLS AMSWLEATAA AAAVTYVDRT QIGKRPPLSP PSREAAGSTM AIDPATRANL
ELTRTLAGER RGSLLDAIDR TMTAAGSRLL AQRLAAPLTD IAAIARRLDA VAAFTSDSAA
RDDIRTILRT APDMSRALAR LSVGRGGPRD LAGLRDGIMA ADRTLARLSA LPDPPQDIVA
AMQALRRPSR ELARELGEAL AENLPLMKRD GGFAREGYEP TLDEARKLRD DSRLVVAAMQ
ARYTEETGVK TLKIRHNNVL GYFVEVTAQH GDKLTSAPLN ATFIHRQTLA GQVRFTTSEL
GEIEARIANA GDRALGLELE IFDRLAAVVV EAGDDLRAAA HAFAQLDVAA SLAKLATDEN
FTRPEVDASL GFAIEGGRHP VVEQALKRAG QPFIANACDL SPGPGQTSGQ IWLLTGPNMA
GKSTFLRQNA LIALMAQIGS FVPATRARIG MIDRLFSRVG AADDLARGRS TFMVEMVETA
VILNQASERA LVILDEIGRG TATFDGLSIA WAAIEHLHEA NKCRALFATH YHELTALSAK
LPRLFNATVR VKEWHGEVVF LHEVLPGAAD RSYGIQVAKL AGLPPSVVAR AKSVLAKLEA
QDRGSTVRAL VDDLPLFAVP SRAADESAPP GEAAPLIEAL KALHPDEMSP REALEALYAL
KAKLPKP
//
