ID MUTS_PARL1 Reviewed; 908 AA.
AC A7HZ64;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Plav_3599;
OS Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Parvibaculaceae; Parvibaculum.
OX NCBI_TaxID=402881;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS-1 / DSM 13023 / NCIMB 13966;
RX PubMed=22675581; DOI=10.4056/sigs.2215005;
RA Schleheck D., Weiss M., Pitluck S., Bruce D., Land M.L., Han S.,
RA Saunders E., Tapia R., Detter C., Brettin T., Han J., Woyke T., Goodwin L.,
RA Pennacchio L., Nolan M., Cook A.M., Kjelleberg S., Thomas T.;
RT "Complete genome sequence of Parvibaculum lavamentivorans type strain (DS-
RT 1(T)).";
RL Stand. Genomic Sci. 5:298-310(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000774; ABS65197.1; -; Genomic_DNA.
DR AlphaFoldDB; A7HZ64; -.
DR SMR; A7HZ64; -.
DR STRING; 402881.Plav_3599; -.
DR KEGG; pla:Plav_3599; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000006377; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..908
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000075558"
FT BINDING 659..666
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 908 AA; 96441 MW; CB311FF747A9DB26 CRC64;
MSEPATSFTP EIPSALPSIP ADATPMMAQY LEIKARWPEA LLFYRMGDFY ELFFEDAVAA
SAALDIALTK RGKHLGEDIP MCGVPVHSHD AYLQRLIRKG FKVAVCEQVE DPAEAKKRGA
KSVVARAVAR LVTPGTLTED TLLDARAHNY LAALSRTGAE AGFGLAWVDV STGDFAVTSL
APVALGAELA RLSPGELLLP ETLDEDEDLA ALLAQSGAAL TRLPAIRFES GQAERRLKSH
LGVSALDGFG AFARAELGAM GALLDYVELT QVGRMPALMP PRRVAATDTM AIDAATRANL
ELVRTLQGET AGSLLATMDR TVTGAGAREL ASRLAAPLTD PAAVNRRLDA VEWFHDARDM
RARLRAGLKS APDIARALSR LSLGRGGPRD LAAIANGLAA AHGLCAALDG ASPSLLPLPE
EIARECEAMR GTAASLQSRL AAMLAEELPL LARDGGFIAR GASPELDETR ALRDDARKLI
AGLQAKYAGE SGIAALKIRH NNVLGYYIEV PPRHGEKLLA PPFSDSYIHR QTMANAMRFT
TAELAGLASR IAEAAGRALE IELALFDELA AATLLEAPSL SRAAEALARL DATAALAELA
AERRYVRPRL DASFAFDIRG GRHPVVEAAL ARTGQAFVPN DTSLSAESGG GKHIWLLTGP
NMAGKSTFLR QNALIAIMAQ MGSFVPADEA HIGVVDRLFS RVGAADDLAR GRSTFMVEMV
ETAAILNQAG ERSLVILDEI GRGTATFDGL SIAWATVEHL HGVNKSRALF ATHYHELTAL
SEKLAHLANA TMRVKEWQGD VVFLHEVAPG AADRSYGIQV AKLAGLPAPV IARAQSVLAA
LEEGGNHEAR TKLIDDLPLF SATAKPAPAV KVSAAEEELK NLNPDELSPK QALELLYKLK
ALAAKDGE
//
