ID MUTS_SACD2 Reviewed; 887 AA.
AC Q21LB1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sde_1256;
OS Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Saccharophagus.
OX NCBI_TaxID=203122;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2-40 / ATCC 43961 / DSM 17024;
RX PubMed=18516288; DOI=10.1371/journal.pgen.1000087;
RA Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M.,
RA Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H.,
RA Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R.,
RA Richardson P.M., Borovok I., Hutcheson S.;
RT "Complete genome sequence of the complex carbohydrate-degrading marine
RT bacterium, Saccharophagus degradans strain 2-40 T.";
RL PLoS Genet. 4:E1000087-E1000087(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000282; ABD80518.1; -; Genomic_DNA.
DR RefSeq; WP_011467738.1; NC_007912.1.
DR AlphaFoldDB; Q21LB1; -.
DR SMR; Q21LB1; -.
DR STRING; 203122.Sde_1256; -.
DR KEGG; sde:Sde_1256; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000001947; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..887
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335222"
FT REGION 828..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 621..628
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 887 AA; 97862 MW; D4F5F2077529A209 CRC64;
MNSTSTATPI ANENHTPMMQ QYLRIKAEHP NEIVFYRMGD FYELFFDDAK KAAKLLDVTL
TARGKSNGEP IPMAGVPYHA AENYLAKLVR LGVSVAIVEQ VGDPATTKGP VERKVMRIVT
PGTVSDEALL DETRDNLLVA ITLKDERYGI SSLDMGSGRF TVFEVADEEA LIGEIERLQP
AELLAPELLT VPNIISLRAG YRRRPDWEFE YDTAQRLLTR HFGTQDLSGF GCEDFTAGIS
AAGCLFAYAQ ETQKTTLSHV AKLVLDNPET KVTLDAATRR NLELDTNLAG TEDNTLFSVL
NTTTTAMGGR LLRRWLHSPL RDIYILNQRQ SAIEALLDNY QFEPLRHTLK HISDLERILG
RLALRSARPR DLSRLCASIA EFPAIQQHLN GIDSPLLKKL AKEIREFPDL VDLLSRALME
NPPVVIREGG VIAEGFDEEL DELRAISTNA GDYLIKLEEQ ERAKTGLSTL KVGYNRVHGY
YIEISKSQAS SAPTEYIRRQ TLKNAERFIT PELKTFEDKA LSAKSRALAR EKGLYDDLIE
TLNEQLRELQ VAASGVAELD VLTTLAERSN LLNFCKPELY EGEGIFIEQG RHPVVEQVLD
DPFVPNDLLL DTDQRMLIIT GPNMGGKSTY MRQTALIVLL AQIGCYVPAS ACKLGLVDRI
FTRIGSSDDL AGGRSTFMVE MTETANILNN ATRNSLVLMD EIGRGTSTYD GLSLAWACVE
HLANNLHAFT LFATHYFELT GLPKALAGVQ NVHLDATEHN DSIVFLHKIQ PGPASKSFGL
QVAKLAGIPS NVIADAGGHL RRLEAQPTVD TPHQFPAPEP IALQEPVAEP EPNKPAAAAK
TKPASPQPDL FASAAPSAVE IKLRSINPDN LTPRQALQAL YDLKDIS
//
