ID MUTS_SYNFM Reviewed; 889 AA.
AC A0LG76;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sfum_0730;
OS Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC Bacteria; Thermodesulfobacteriota; Syntrophobacteria; Syntrophobacterales;
OC Syntrophobacteraceae; Syntrophobacter.
OX NCBI_TaxID=335543;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10017 / MPOB;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000478; ABK16428.1; -; Genomic_DNA.
DR RefSeq; WP_011697601.1; NC_008554.1.
DR AlphaFoldDB; A0LG76; -.
DR SMR; A0LG76; -.
DR STRING; 335543.Sfum_0730; -.
DR KEGG; sfu:Sfum_0730; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_7; -.
DR InParanoid; A0LG76; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000001784; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..889
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000071280"
FT REGION 812..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 889 AA; 98981 MW; 2C52F3FC50F3B9FD CRC64;
MNKITPMMQQ YLEIKEKYPD ALLLYRMGDF YEMFMDDAVT ASGLLEIALT SRDRQSEVRI
PMCGVPYHAA EGYIARLVSA GKKVAICDQV EDPRKAKGLV RREVTRVITP GLVLDAQNLA
AKQPNYLAAV SNSTAGERFG LAFLDVSTAE FKMVEIESRE ALLEELIRVS PRELLLSDDD
EHPWAEELPK LYGIALTPLG ADRFDGKRAE EALVGHFRVH SLEGFGISGM DLGIRAAGAI
LAYMQANLLG SCDHITRLLP YSRGDFMIVD EAGVRNLEIF HSQSFQGRKG SLIDILDETK
TAMGGRKLQQ WLRYPLLDLA RINNRREAIA ELAANAPMRG ETLGLLSRIS DVERLNGRNS
TGTSTPRDLV ALKKSLQNLP ALGAALAELT SPRLSELRAR WDDLADVADI IERTLLDPPP
PGLAAGGVIS AGVSEELDHF VRLSRDAKGW MADYEVQQRR DTGISSLKVR YNKVFGYYIE
ISNANLNSVP EHYFRKQTLV NAERFITEEL KTFETQVLQA EEKRLELEQQ IFADLRARIA
REAGRIQAAA DRIADLDCVS ALAEVACRYD YCRPVMDESD AIRIRDGRHP VIEHYLKDGT
FVPNDLDMDQ RDQQVLVITG PNMAGKSTIL RQAALIVLMG HIGSFVPASE AHIGLVDRIF
TRVGASDDLA RGRSTFMVEM QETANILHHA TPRSLIILDE IGRGTSTYDG LSIAWAVAEH
LHDFQEKGIK TLFATHYHEL TELARSRPRV RNFNVAIREW QQEILFFHKL VQGGASRSYG
IQVARLAGLP EEVTGRAREI LQQLESGHAP FAAAPSGAAR RGRPAREKEP GIQMSLFQRS
PEWLRDRILA LDLDNMTPIA ALQNLHALKE QIRGSAGEEP ASCASRGKR
//
