ID MY119_ARATH Reviewed; 430 AA.
AC Q9FIM4; A0MFQ4;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 172.
DE RecName: Full=Transcription factor MYB119 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 119 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB119 {ECO:0000303|PubMed:11597504};
GN Name=MYB119 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At5g58850 {ECO:0000312|Araport:AT5G58850};
GN ORFNames=K19M22.5 {ECO:0000312|EMBL:BAB09630.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=24068955; DOI=10.1371/journal.pgen.1003783;
RA Rabiger D.S., Drews G.N.;
RT "MYB64 and MYB119 are required for cellularization and differentiation
RT during female gametogenesis in Arabidopsis thaliana.";
RL PLoS Genet. 9:E1003783-E1003783(2013).
CC -!- FUNCTION: Transcription factor required for female gametophyte
CC fertility. Acts redundantly with MYB64 to initiate the FG5 transition
CC during female gametophyte development. The FG5 transition represents
CC the switch between free nuclear divisions and cellularization-
CC differentiation in female gametophyte, and occurs during developmental
CC stage FG5. {ECO:0000269|PubMed:24068955}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:24068955}.
CC -!- TISSUE SPECIFICITY: Expressed in ovary septum and stamen filament.
CC {ECO:0000269|PubMed:24068955}.
CC -!- DEVELOPMENTAL STAGE: During female gametogenesis, expressed in the
CC female gametophyte at stage FG4 (four-nucleate stage) in all four
CC nuclei. Expressed in the central cell in unfused polar nuclei at stage
CC FG5 and secondary nucleus at stage FG6. Not expressed in mature female
CC gametophytes (stage FG7). {ECO:0000269|PubMed:24068955}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but in the double mutant plants myb64 and myb119 the female
CC gametophytes fail to cellularize, resulting in enlarged coenocytes with
CC supernumerary nuclei. {ECO:0000269|PubMed:24068955}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28765.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF371978; AAK54741.1; -; mRNA.
DR EMBL; AB016885; BAB09630.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97110.1; -; Genomic_DNA.
DR EMBL; DQ447091; ABE66260.1; -; mRNA.
DR EMBL; DQ653380; ABK28765.1; ALT_SEQ; mRNA.
DR RefSeq; NP_568891.1; NM_125275.2.
DR AlphaFoldDB; Q9FIM4; -.
DR SMR; Q9FIM4; -.
DR STRING; 3702.Q9FIM4; -.
DR PaxDb; 3702-AT5G58850-1; -.
DR EnsemblPlants; AT5G58850.1; AT5G58850.1; AT5G58850.
DR GeneID; 836002; -.
DR Gramene; AT5G58850.1; AT5G58850.1; AT5G58850.
DR KEGG; ath:AT5G58850; -.
DR Araport; AT5G58850; -.
DR TAIR; AT5G58850; MYB119.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_034700_1_0_1; -.
DR InParanoid; Q9FIM4; -.
DR OMA; HKSVWTH; -.
DR OrthoDB; 507081at2759; -.
DR PhylomeDB; Q9FIM4; -.
DR PRO; PR:Q9FIM4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIM4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45614:SF218; MYB DOMAIN PROTEIN 100-RELATED; 1.
DR PANTHER; PTHR45614; MYB PROTEIN-RELATED; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..430
FT /note="Transcription factor MYB119"
FT /id="PRO_0000440861"
FT DOMAIN 100..155
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 156..206
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 128..151
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 179..202
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 53..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 48513 MW; 9055F00773533C7B CRC64;
MEDRRLVHGA APPLTAVERF LYGQKNDALC SKKQESSRDQ PIVKTKISIE TRSDNKENTT
FGPTREKHLV LNGGNRNPTG EVVARSAARD YQNSTKKRSS KNLIKGQWTA EEDRKLIRLV
RQHGERKWAM ISEKLEGRAG KQCRERWHNH LRPDIKKDGW SEEEERVLVE SHMRIGNKWA
EIAKLIPGRT ENSIKNHWNA TKRRQNSKRK HKRESNADNN DRDASPSAKR PCILQDYIKS
IERNNINKDN DEKKNENTIS VISTPNLDQI YSDGDSASSI LGGPYDEELD YFQNIFANHP
ISLENLGLSQ TSDEVTQSSS SGFMIKNPNP NLHDSVGIHH QEATITAPAN TPHLASDIYL
SYLLNGTTSS YSDTHFPSSS SSTSSTTVEH GGHNEFLEPQ ANSTSERREM DLIEMLSGSI
QGSNICFPLV
//
