ID MYCB_MOUSE Reviewed; 170 AA.
AC Q6P8Z1; Q9D6E3;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 135.
DE RecName: Full=Protein B-Myc;
GN Name=Mycb; Synonyms=Bmyc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Hippocampus, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-60 AND SER-68,
RP PHOSPHORYLATION AT SER-60 AND SER-68, AND TISSUE SPECIFICITY.
RX PubMed=11039906; DOI=10.1038/sj.onc.1203851;
RA Gregory M.A., Xiao Q., Cornwall G.A., Lutterbach B., Hann S.R.;
RT "B-Myc is preferentially expressed in hormonally-controlled tissues and
RT inhibits cellular proliferation.";
RL Oncogene 19:4886-4895(2000).
CC -!- FUNCTION: Seems to act as an inhibitor of cellular proliferation.
CC {ECO:0000269|PubMed:11039906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11039906}.
CC -!- TISSUE SPECIFICITY: Highly expressed in epididymis. Also expressed in
CC hypothalamus, pituitary, uterus and ovary. Low expression in testis.
CC Not detected in heart. {ECO:0000269|PubMed:11039906}.
CC -!- PTM: Rapidly degraded via the ubiquitin-proteasome pathway.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28992.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK012810; BAE43234.1; -; mRNA.
DR EMBL; AK013780; BAB28992.1; ALT_FRAME; mRNA.
DR EMBL; AK158603; BAE34577.1; -; mRNA.
DR EMBL; BC061001; AAH61001.1; -; mRNA.
DR CCDS; CCDS15789.1; -.
DR RefSeq; NP_075815.2; NM_023326.2.
DR AlphaFoldDB; Q6P8Z1; -.
DR IntAct; Q6P8Z1; 3.
DR MINT; Q6P8Z1; -.
DR STRING; 10090.ENSMUSP00000097885; -.
DR iPTMnet; Q6P8Z1; -.
DR PhosphoSitePlus; Q6P8Z1; -.
DR PaxDb; 10090-ENSMUSP00000097885; -.
DR ProteomicsDB; 287561; -.
DR DNASU; 107771; -.
DR Ensembl; ENSMUST00000061483.9; ENSMUSP00000097885.5; ENSMUSG00000049086.9.
DR GeneID; 107771; -.
DR KEGG; mmu:107771; -.
DR UCSC; uc008itg.1; mouse.
DR AGR; MGI:88184; -.
DR CTD; 107771; -.
DR MGI; MGI:88184; Bmyc.
DR VEuPathDB; HostDB:ENSMUSG00000049086; -.
DR eggNOG; KOG2483; Eukaryota.
DR GeneTree; ENSGT00940000155285; -.
DR HOGENOM; CLU_135109_0_0_1; -.
DR InParanoid; Q6P8Z1; -.
DR OMA; PDCTCNT; -.
DR OrthoDB; 3039999at2759; -.
DR PhylomeDB; Q6P8Z1; -.
DR BioGRID-ORCS; 107771; 1 hit in 81 CRISPR screens.
DR ChiTaRS; Bmyc; mouse.
DR PRO; PR:Q6P8Z1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6P8Z1; Protein.
DR Bgee; ENSMUSG00000049086; Expressed in embryonic brain and 217 other cell types or tissues.
DR ExpressionAtlas; Q6P8Z1; baseline and differential.
DR Genevisible; Q6P8Z1; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0071943; C:Myc-Max complex; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0090571; C:RNA polymerase II transcription repressor complex; ISO:MGI.
DR GO; GO:0005819; C:spindle; IDA:MGI.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0070888; F:E-box binding; ISO:MGI.
DR GO; GO:0060090; F:molecular adaptor activity; EXP:DisProt.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1905761; F:SCF ubiquitin ligase complex binding; ISO:MGI.
DR GO; GO:0001221; F:transcription coregulator binding; ISO:MGI.
DR GO; GO:0071456; P:cellular response to hypoxia; ISO:MGI.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; ISO:MGI.
DR GO; GO:0006338; P:chromatin remodeling; ISO:MGI.
DR GO; GO:0051276; P:chromosome organization; ISO:MGI.
DR GO; GO:0006974; P:DNA damage response; ISO:MGI.
DR GO; GO:0006346; P:DNA methylation-dependent heterochromatin formation; ISO:MGI.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISO:MGI.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; ISO:MGI.
DR GO; GO:0000165; P:MAPK cascade; ISO:MGI.
DR GO; GO:0051782; P:negative regulation of cell division; ISO:MGI.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; ISO:MGI.
DR GO; GO:0045656; P:negative regulation of monocyte differentiation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:MGI.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:MGI.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; ISO:MGI.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0032986; P:protein-DNA complex disassembly; ISO:MGI.
DR GO; GO:0010564; P:regulation of cell cycle process; ISO:MGI.
DR GO; GO:0032204; P:regulation of telomere maintenance; ISO:MGI.
DR GO; GO:0010332; P:response to gamma radiation; ISO:MGI.
DR DisProt; DP00564; -.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR PANTHER; PTHR45851:SF1; MYC PROTO-ONCOGENE PROTEIN; 1.
DR Pfam; PF01056; Myc_N; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..170
FT /note="Protein B-Myc"
FT /id="PRO_0000127339"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:11039906"
FT MOD_RES 68
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:11039906"
FT MUTAGEN 60
FT /note="S->A: Loss of phosphorylation."
FT /evidence="ECO:0000269|PubMed:11039906"
FT MUTAGEN 68
FT /note="S->A: Loss of phosphorylation."
FT /evidence="ECO:0000269|PubMed:11039906"
SQ SEQUENCE 170 AA; 18526 MW; EF3BD10DD793C2D4 CRC64;
MPLHVSLANG NRDLDYDSVQ PYFMCDDEEE DVHHQQPPQP PAPSEDIWKK FELLPTPRPS
PGHAGLYSPP CEAVAVSFAP RDHDGDSFSI ADLPELPGGD AVKQSFVCDP DDETFVKNII
LQDCMWNGFS ASAKLVSKLD PYQAVRKEGT GVSLAADVEP ATPPDCTCNT
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