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Database: UniProt
Entry: MYCT1_MOUSE
LinkDB: MYCT1_MOUSE
Original site: MYCT1_MOUSE 
ID   MYCT1_MOUSE             Reviewed;         188 AA.
AC   Q8R411; Q3UQ11; Q8C6M8; Q9D182;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   17-JUN-2020, entry version 105.
DE   RecName: Full=Myc target protein 1;
DE   AltName: Full=Myc target in myeloid cells protein 1;
GN   Name=Myct1; Synonyms=Mtmc1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=11909865; DOI=10.1074/jbc.m200860200;
RA   Yin X., Grove L., Rogulski K., Prochownik E.V.;
RT   "Myc target in myeloid cells-1, a novel c-Myc target, recapitulates
RT   multiple c-Myc phenotypes.";
RL   J. Biol. Chem. 277:19998-20010(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Head, Lung, and Oviduct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87; SER-90; SER-93 AND
RP   SER-101, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, and
RC   Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May regulate certain MYC target genes, MYC seems to be a
CC       direct upstream transcriptional activator. Does not seem to
CC       significantly affect growth cell capacity. Overexpression seems to
CC       mediate many of the known phenotypic features associated with MYC,
CC       including promotion of apoptosis, alteration of morphology, enhancement
CC       of anchorage-independent growth, tumorigenic conversion, promotion of
CC       genomic instability and inhibition of hematopoietic differentiation.
CC       {ECO:0000269|PubMed:11909865}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in lung, heart, and skeletal
CC       muscle. Expressed in brain, eye, liver, kidney, smooth muscle,
CC       pancreas, thyroid, thymus, submaxillary gland, spleen, testis, ovary,
CC       prostate, epididymis, and uterus. Deregulated expression promotes
CC       apoptosis in response to growth factor deprivation. Overexpression in
CC       synergy with CCNB1 may promote genomic instability.
CC       {ECO:0000269|PubMed:11909865}.
CC   -!- DEVELOPMENTAL STAGE: Low levels of expression seen in 7-, 11-, 15- and
CC       17-day embryos. {ECO:0000269|PubMed:11909865}.
CC   -!- SIMILARITY: Belongs to the MYCT1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC35696.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE25233.1; Type=Frameshift; Evidence={ECO:0000305};
DR   EMBL; AY090114; AAM14631.1; -; mRNA.
DR   EMBL; AK030706; BAE20454.1; -; mRNA.
DR   EMBL; AK003845; BAB23032.1; -; mRNA.
DR   EMBL; AK054222; BAC35696.1; ALT_INIT; mRNA.
DR   EMBL; AK142963; BAE25233.1; ALT_FRAME; mRNA.
DR   EMBL; AF499468; AAM22183.1; -; Genomic_DNA.
DR   EMBL; BC096559; AAH96559.1; -; mRNA.
DR   CCDS; CCDS56681.1; -.
DR   RefSeq; NP_081069.1; NM_026793.2.
DR   BioGRID; 212964; 1.
DR   STRING; 10090.ENSMUSP00000050430; -.
DR   iPTMnet; Q8R411; -.
DR   PhosphoSitePlus; Q8R411; -.
DR   MaxQB; Q8R411; -.
DR   PaxDb; Q8R411; -.
DR   PRIDE; Q8R411; -.
DR   Antibodypedia; 55356; 122 antibodies.
DR   Ensembl; ENSMUST00000051809; ENSMUSP00000050430; ENSMUSG00000046916.
DR   GeneID; 68632; -.
DR   KEGG; mmu:68632; -.
DR   UCSC; uc007egl.2; mouse.
DR   CTD; 80177; -.
DR   MGI; MGI:1915882; Myct1.
DR   eggNOG; ENOG410IE0H; Eukaryota.
DR   eggNOG; ENOG4111XBR; LUCA.
DR   GeneTree; ENSGT00390000011642; -.
DR   HOGENOM; CLU_104680_0_0_1; -.
DR   InParanoid; Q8R411; -.
DR   OMA; ENFWEDL; -.
DR   OrthoDB; 1364750at2759; -.
DR   PhylomeDB; Q8R411; -.
DR   TreeFam; TF333196; -.
DR   BioGRID-ORCS; 68632; 0 hits in 12 CRISPR screens.
DR   ChiTaRS; Myct1; mouse.
DR   PRO; PR:Q8R411; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q8R411; protein.
DR   Bgee; ENSMUSG00000046916; Expressed in lung and 180 other tissues.
DR   Genevisible; Q8R411; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   InterPro; IPR029180; Myc_target_1.
DR   PANTHER; PTHR14869; PTHR14869; 1.
DR   Pfam; PF15179; Myc_target_1; 1.
PE   1: Evidence at protein level;
KW   Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..188
FT                   /note="Myc target protein 1"
FT                   /id="PRO_0000310960"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           47..65
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        47..50
FT                   /note="Poly-Arg"
FT   COMPBIAS        173..176
FT                   /note="Poly-Pro"
FT   MOD_RES         87
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:17242355,
FT                   ECO:0000244|PubMed:21183079"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:21183079"
FT   MOD_RES         93
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:21183079"
FT   MOD_RES         101
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:21183079"
FT   CONFLICT        16
FT                   /note="F -> L (in Ref. 2; BAB23032)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173
FT                   /note="P -> R (in Ref. 2; BAE25233)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   188 AA;  21079 MW;  7B4FC2D5CE66929B CRC64;
     MANNTTSLGS PWPENFWEDL IMSFTVSVAI GLAIGGFLWA LFVFLSRRRR ASAPISQWSP
     TRRPRSSYNH GLNRTGFYRH SGYERRSNLS LASLTFQRQA SMELVNSFPR KSSFRASTFH
     PFLQCPPLPV ETESQLMTLS ASTTPSTLST AHSPSRPDFR WSSNSLRMGL STPPPPAYES
     IIKAFPDS
//
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