ID MYH7B_MOUSE Reviewed; 1941 AA.
AC A2AQP0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 24-JAN-2024, entry version 118.
DE RecName: Full=Myosin-7B;
DE AltName: Full=Myosin cardiac muscle beta chain;
DE AltName: Full=Myosin heavy chain 7B, cardiac muscle beta isoform;
GN Name=Myh7b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Involved in muscle contraction. {ECO:0000250}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin,
CC while the beta isoform is a 'slow' ATPase.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
CC -!- CAUTION: Represents a conventional myosin. This protein should not be
CC confused with the unconventional myosin-7 (MYO7). {ECO:0000305}.
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DR EMBL; AL844852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50768.1; -.
DR RefSeq; NP_001078847.1; NM_001085378.2.
DR AlphaFoldDB; A2AQP0; -.
DR SMR; A2AQP0; -.
DR BioGRID; 580721; 1.
DR STRING; 10090.ENSMUSP00000090672; -.
DR GlyGen; A2AQP0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A2AQP0; -.
DR PhosphoSitePlus; A2AQP0; -.
DR EPD; A2AQP0; -.
DR MaxQB; A2AQP0; -.
DR PaxDb; 10090-ENSMUSP00000090672; -.
DR PeptideAtlas; A2AQP0; -.
DR ProteomicsDB; 293596; -.
DR Antibodypedia; 54800; 52 antibodies from 9 providers.
DR Ensembl; ENSMUST00000092995.6; ENSMUSP00000090672.6; ENSMUSG00000074652.4.
DR GeneID; 668940; -.
DR KEGG; mmu:668940; -.
DR UCSC; uc008nla.2; mouse.
DR AGR; MGI:3710243; -.
DR CTD; 57644; -.
DR MGI; MGI:3710243; Myh7b.
DR VEuPathDB; HostDB:ENSMUSG00000074652; -.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000160950; -.
DR HOGENOM; CLU_000192_8_1_1; -.
DR InParanoid; A2AQP0; -.
DR OMA; CYLRQGY; -.
DR OrthoDB; 2877572at2759; -.
DR PhylomeDB; A2AQP0; -.
DR TreeFam; TF314375; -.
DR BioGRID-ORCS; 668940; 1 hit in 78 CRISPR screens.
DR PRO; PR:A2AQP0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2AQP0; Protein.
DR Bgee; ENSMUSG00000074652; Expressed in mesenchyme of forearm and 90 other cell types or tissues.
DR Genevisible; A2AQP0; MM.
DR GO; GO:0097512; C:cardiac myofibril; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0050848; P:regulation of calcium-mediated signaling; ISO:MGI.
DR GO; GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; ISO:MGI.
DR GO; GO:0086004; P:regulation of cardiac muscle cell contraction; ISO:MGI.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:MGI.
DR CDD; cd14927; MYSc_Myh7b; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF29; MYOSIN-7B; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding; ATP-binding; Coiled coil; Membrane; Motor protein;
KW Muscle protein; Myosin; Nucleotide-binding; Reference proteome;
KW Thick filament.
FT CHAIN 1..1941
FT /note="Myosin-7B"
FT /id="PRO_0000349313"
FT DOMAIN 30..80
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01190"
FT DOMAIN 84..785
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 788..817
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 662..684
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 764..778
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 1887..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 846..1935
FT /evidence="ECO:0000255"
FT COMPBIAS 1904..1941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 177..184
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1941 AA; 221497 MW; 6F1F88B2D563A94E CRC64;
MMDMSELGES ACYLRQGYQE MMKVHTVPWD GKKRVWVPDE QDAYVEAEVK TEATGGKVTV
ETKDQKVLTV RETEMQPMNP PRFDLLEDMA MMTHLNEAAV LHNLRQRYAR WMIYTYSGLF
CVTINPYKWL PVYTAAVVAA YKGKRRSEAP PHIYAVADNA YNDMLRNREN QSMLITGESG
AGKTVNTKRV IQYFAIVAAL GDGPGKKAQF LATKTGGTLE DQIIEANPAM EAFGNAKTLR
NDNSSRFGKF IRIHFGPTGK LASADIDSYL LEKSRVIFQL PGERGYHVYY QILSGKKPEL
QDMLLLSMNP YDYHFCSQGV TTVDNMDDGE ELIATDHAMD ILGFSVDEKC ACYKIVGALL
HFGNMKFKQK QREEQAEADG TESADKAAYL MGVSSGDLLK GLLHPRVRVG NEYVTKGQSV
EQVVFAVGAL AKATYDRLFR WLVSRINQTL DTKLPRQFFI GVLDIAGFEI FEFNSFEQLC
INFTNEKLQQ FFNQHMFVLE QEEYKREGID WVFIDFGLDL QPCIDLIEKP LGILSILEEE
CMFPKASDAS FRAKLYDNHS GKSPNFQQPR PDKKRKYQAH FEVVHYAGVV PYSIVGWLEK
NKDPLNETVV PIFQKSQNRL LATLYENYAG SCSTEPPKSG VKEKRKKAAS FQTVSQLHKE
NLNKLMTNLR ATQPHFVRCI VPNENKTPGV MDSFLVLHQL RCNGVLEGIR ICRQGFPNRL
LYADFRQRYR ILNPSAIPDD TFVDSRKATE KLLGSLDIDH TQYQFGHTKV FFKAGLLGIL
EELRDQRLAK VLTLLQARSR GRLMRLEYQR MLGGRDALFT IQWNIRAFNA VKNWSWMKLF
FKMKPLLRSA QAEEELAALR AELRGLRGAL ATAEAKRQEL EETQVSVTQE KNDLALQLQA
EQDNLADAEE RCHLLIKSKV QLEAKVKELS ERLEDEEEVN ADLAARRRKL EDECTELKKD
IDDLELTLAK AEKEKQATEN KVKNLTEEMA ALDEAVVRLT KEKKALQEAH QQALGDLQAE
EDRVSALAKA KIRLEQQVED LECSLEQEKK LRMDTERAKR KLEGDLKLTQ ETVTDTTQDK
QQLEEKLKKK DSELSQLNLR VEDEQLVGVQ LQKKIKELQA RAEELEEELE AERAARARVE
KQRAEAAREL EELSERLEEA GGASAGQREG CRKREAELGR LRRELEEAVL RHEATVAALR
RKQADSAAEL SEQVDSLQRI RQKLEKEKSE LRMEVDDLGA SVETLARGKA SAEKLCRTYE
DQLSEAKIKV EELQRQLADA STQRGRLQTE NGELGRLLEE KESMISQLSR GKTSAAQSLE
ELRRQLEEES KAKGALAHAV QALRHDCDLL REQHEEESEA QAELQRLLSK ANAEVAQWRS
KYEADAIQRT EELEEAKKKL ALRLQEAEEG VEAANAKCSS LEKAKLRLQT ESEDVTLELE
RATSAAAALD KKQRHLERAL EERRRQEEEM QRELEAAQRE ARGLGTELFR LRHSHEEALE
ALETLKRENK NLQEEISDLT DQVSLSGKSI QELEKAKKAL EGEKSELQAA LEEAEGALEL
EETKTLRIQL ELSQVKAEVD RKLAEKDEEC TNLRRNHQRA VESLQASLDA ETRARNEALR
LKKKMEGDLN DLELQLGHAT RQAMEAQAAT RLLQAQLKEE QAGRDEEQRL AAELREQGQA
LERRAALLAA ELEELRAALE QGERSRRLAE QELLEATERL NLLHSQNTGL LNQKKKLEVD
LAQLSGEVEE AAQERREAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KTLEQTVREL
QARLEEAEQA ALRGGKKQVQ KLEAKVRELE AELDAEQKKH AEALKGVRKH ERRVKELVYQ
TEEDRKNLAR MQDLVDKLQS KVKSYKRQFE EAEQQASTNL AKYRKAQHEL DDAEERADMA
ETQANKLRAR SRDALGPKHK E
//
