ID MYO10_ARATH Reviewed; 1770 AA.
AC F4IVR7; Q8RYE8;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Myosin-10;
DE AltName: Full=Myosin XI D;
DE Short=AtXID;
GN Name=XI-D; Synonyms=XID; OrderedLocusNames=At2g33240; ORFNames=F25I18.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=10984423; DOI=10.1242/jcs.113.19.3353;
RA Hodge T., Cope M.J.;
RT "A myosin family tree.";
RL J. Cell Sci. 113:3353-3354(2000).
RN [4]
RP GENE FAMILY.
RX PubMed=11516337; DOI=10.1186/gb-2001-2-7-research0024;
RA Reddy A.S., Day I.S.;
RT "Analysis of the myosins encoded in the recently completed Arabidopsis
RT thaliana genome sequence.";
RL Genome Biol. 2:RESEARCH0024.1-RESEARCH0024.17(2001).
RN [5]
RP ALTERNATIVE SPLICING (ISOFORM 2).
RX PubMed=19369591; DOI=10.1104/pp.109.136853;
RA Avisar D., Abu-Abied M., Belausov E., Sadot E., Hawes C., Sparkes I.A.;
RT "A comparative study of the involvement of 17 Arabidopsis myosin family
RT members on the motility of Golgi and other organelles.";
RL Plant Physiol. 150:700-709(2009).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21233331; DOI=10.1104/pp.110.170720;
RA Peremyslov V.V., Mockler T.C., Filichkin S.A., Fox S.E., Jaiswal P.,
RA Makarova K.S., Koonin E.V., Dolja V.V.;
RT "Expression, splicing, and evolution of the myosin gene family in plants.";
RL Plant Physiol. 155:1191-1204(2011).
CC -!- FUNCTION: Myosin heavy chain that is required for the cell cycle-
CC regulated transport of various organelles and proteins for their
CC segregation. Functions by binding with its tail domain to receptor
CC proteins on organelles and exerting force with its N-terminal motor
CC domain against actin filaments, thereby transporting its cargo along
CC polarized actin cables (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IVR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IVR7-2; Sequence=VSP_047340;
CC -!- DOMAIN: IQ domain mediates interaction with calmodulin. {ECO:0000250}.
CC -!- DOMAIN: The tail domain is a globular cargo-binding domain.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. Plant myosin class XI subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM14807.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002334; AAM14807.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08804.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62028.1; -; Genomic_DNA.
DR PIR; A84743; A84743.
DR RefSeq; NP_001324211.1; NM_001336436.1. [F4IVR7-2]
DR RefSeq; NP_180882.2; NM_128883.3. [F4IVR7-1]
DR AlphaFoldDB; F4IVR7; -.
DR SMR; F4IVR7; -.
DR STRING; 3702.F4IVR7; -.
DR iPTMnet; F4IVR7; -.
DR PaxDb; 3702-AT2G33240-1; -.
DR EnsemblPlants; AT2G33240.1; AT2G33240.1; AT2G33240. [F4IVR7-1]
DR EnsemblPlants; AT2G33240.4; AT2G33240.4; AT2G33240. [F4IVR7-2]
DR GeneID; 817886; -.
DR Gramene; AT2G33240.1; AT2G33240.1; AT2G33240. [F4IVR7-1]
DR Gramene; AT2G33240.4; AT2G33240.4; AT2G33240. [F4IVR7-2]
DR KEGG; ath:AT2G33240; -.
DR Araport; AT2G33240; -.
DR TAIR; AT2G33240; XID.
DR eggNOG; KOG0160; Eukaryota.
DR HOGENOM; CLU_000192_3_1_1; -.
DR InParanoid; F4IVR7; -.
DR OrthoDB; 664095at2759; -.
DR PRO; PR:F4IVR7; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IVR7; baseline and differential.
DR Genevisible; F4IVR7; AT.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISS:TAIR.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0030048; P:actin filament-based movement; TAS:TAIR.
DR CDD; cd15475; MyosinXI_CBD; 1.
DR CDD; cd01384; MYSc_Myo11; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR037975; MyosinXI_CBD.
DR InterPro; IPR036018; MYSc_Myo11.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF797; MYOSIN-10; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding;
KW Coiled coil; Motor protein; Myosin; Nucleotide-binding; Reference proteome;
KW Repeat.
FT CHAIN 1..1770
FT /note="Myosin-10"
FT /id="PRO_0000422865"
FT DOMAIN 25..73
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01190"
FT DOMAIN 78..748
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 774..803
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 799..828
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 822..851
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 847..876
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 870..899
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1347..1718
FT /note="Dilute"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00503"
FT REGION 511..545
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 547..570
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 605..629
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 629..651
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 1388..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 900..1253
FT /evidence="ECO:0000255"
FT COMPBIAS 1491..1510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 225..233
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1256..1268
FT /note="KSLDLFVFMYLFQ -> VSFTRPP (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047340"
SQ SEQUENCE 1770 AA; 200639 MW; 56084D27F0EB6574 CRC64;
MVWKHQLIGF SGIFSNVSPA SVKVTVGSQV WVEDPDEAWL DGEVVEANGQ EIKVNCQTKT
VVAKVNAVHP KDPEFPELGV DDMTKLAYLH EPGVLLNLKA RYNANEIYTY TGNILIAVNP
FKRLPHLYGN EIMEQYKGTD FGELSPHPFA VADSAYRKMI NEGVSQAILV SGESGAGKTE
STKMLMQYLA YMGGKAESEG RSVEQQVLES NPVLEAFGNA KTVRNNNSSR FGKFVEIQFN
HMGRISGAAI RTYLLERSRV CQVSDPERNY HCFYMLCAAP EQETERYQLG KPSTFHYLNQ
SNCHALDAID DSKEYLATRK AMDVVGISPE EQDAIFRVVA AILHLGNIEF AKSEESDGAE
PKDDKSRFHL KVAAKLFMCD EKALENSLCN RVMVTRGESI TKPLDPGSAA LSRDALAKIV
YSKLFDWLVT KINNSIGQDS SSKYIIGVLD IYGFESFKTN SFEQFCINLT NEKLQQHFNQ
HVFKMEQEEY TKEEIDWSYI EFIDNQDVLD LIEKKPGGII ALLDEACMFP RSTHDTLAEK
LYQTFGSHKR FTKPKLARTD FTICHYAGDV TYQTELFLDK NKDYVVGEHQ SLMNSSDCSF
VSSLFPKSRE ESSKSSKFSS IGSQFKQQLQ SLLETLNTTE PHYIRCVKPN NVLKPEIFEN
VNVLHQLRCG GVMEAIRISC AGYPTRKPFN EFLTRFRILA PEATERSFDE VDACKKLLAR
VDLKGFQIGK TKVFLRAGQM AELDAHRAEV LGHSARIIQR KVITYLSRKK YLLLQSASTE
IQAFCRGHIA RVQFKATRRE AASVRIQKQA RTYICQTAFK KLCASAISIQ SGLRAMAARV
EFQYRTKRKA AIIIQSQIRR CLCRRRYLRT KKAAITTQCG WRVKVAHREL RKLKMAAKET
GALQDAKTKL EKEVEELTSC LELEKQMRME LEQVKTQEVE DLRSALNDMK LQLGETQVTK
SEEILKLQSA LQDMQLEFEE LAKELEMTND LAAENEQLKD LVSSLQRKID ESDSKYEETS
KLSEERVKQE VPVIDQGVII KLEAENQKLK ALVSTLEKKI DSLDRKHDVT SSNISDQLKE
SASSDYEMLS NLAAENERLK ALVSSLENEN YENDGNDSPN EQKEGPQMLK EEILAEDFSI
DDEMTNKLAA ENKDLYDLVD LLERKIDETE KKYEEASKLC EERLKQVVDT EKKYEEASRL
CEERLKQVVD TETKLIELKT SMQRLEEKVS DMEAEDKILR QQALRNSASR KMSPQKSLDL
FVFMYLFQPV ENGHHESFAP IPSRRFGAMS FRRSQIEQQP HEFVDVLLKC VSKNVGFSHG
KPVAAFTIYK CLIHWKLFEA EKTSVFDRIV PIFGSAIENP EDDSNLAYWL TNTSTLLFLL
QRSLKSHSTT GASPKKPPQP TSFFGRMTQG FRSPSSASLS GDVVQQVDAR YPALLFKQQL
TAYIETIYGI FQENVKRKLA PVLSSCIQGL KDSSHEFSAE TLSAESSEQN SPEKPSEENP
PEKLSEDNSS GKLSEDYLAA KPSEDNSPAK PSEENSQAKL SEVNPQAKPS AENSLAKPSE
ENSPTETWQD VIGLLNQLLG TLKKNYVPLF LAQKIFCQTF QDINVQLFNS LLQRECCTFI
MGKKVNVWLN ELESWCSQAT EDFVGSSWDE LKNTRQALVL LVTEQKSTIT YDDLTTNLCP
ALSTQQLYRI CTLCKIDDHE DQNVSPDVIS NLKLLVTDED EDSRSFLLDN NSSIPFAADE
ISNSMQEKDF TNVKPAVELA DNPNFHFLKE
//
