ID N0ASY3_9BACI Unreviewed; 881 AA.
AC N0ASY3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=B1NLA3E_06865 {ECO:0000313|EMBL:AGK53137.1};
OS Bacillus sp. 1NLA3E.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=666686 {ECO:0000313|EMBL:AGK53137.1, ECO:0000313|Proteomes:UP000013300};
RN [1] {ECO:0000313|EMBL:AGK53137.1, ECO:0000313|Proteomes:UP000013300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1NLA3E {ECO:0000313|EMBL:AGK53137.1};
RX PubMed=23833140;
RA Venkatramanan R., Prakash O., Woyke T., Chain P., Goodwin L.A., Watson D.,
RA Brooks S., Kostka J.E., Green S.J.;
RT "Genome sequences for three denitrifying bacterial strains isolated from a
RT uranium- and nitrate-contaminated subsurface environment.";
RL Genome Announc. 1:e00449-13(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP005586; AGK53137.1; -; Genomic_DNA.
DR RefSeq; WP_015593197.1; NC_021171.1.
DR AlphaFoldDB; N0ASY3; -.
DR STRING; 666686.B1NLA3E_06865; -.
DR KEGG; baci:B1NLA3E_06865; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000013300; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000013300}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 779..806
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 881 AA; 101292 MW; 9EBB60339C5C2048 CRC64;
MAAYTPMIQQ YLQVKADYQD AFLFFRLGDF YEMFFDDAIS ASQELEITLT SRDGGGEGKI
PMCGVPHHAA PQYIEQLIEK GYKVAICEQT EDPRQAKGVV KREVVQLITP GTMMEGRGLS
EKENNYLASI TVFEDQTYGF AYNDLSTGEN RVTLLSGSFD EVLNELSISG AKEVVIATSF
PDELQRKIRE RSVVTLSFED DLTIQDFYSP LLKEIDLLTK RQTVARLLNY LYRTQKRSLD
HLQPVSQYEV QHYMKIDYYS KRNLELTETI RSKGKKGSLI WLLDETKTAM GGRLLKQWID
RPLIDRDEIQ HRHSLVETFL AHYFERQDLR EKLTEVYDLE RLSGRVAFGN VNARDLVQLK
RSLWQIPGIK QLIGELPNET AVALAEQLDP CEDVTDLLER ALVENPPISL KEGNIIQDGY
HEELDRYRDA SRNGKTWIAQ LERQEREKTG IKSLKIGYNR VFGYYIEITR ANLHLLQDDL
YERKQTLSNA ERFITPELKE KEELILQAEE KIVELEYQLF SEIRERIKEY IPHLQALAKR
ISELDVLQCF ATISENRHYV KPLFSDERRI FIKEGRHPVV EKVMNAQEYV PNDCHMDRDR
EILLITGPNM SGKSTYMRQV ALTAILAQIG CYVPATEAVL PIFDQVFTRI GAADDLISGQ
STFMVEMLEA KNAITNATQA SLILFDEIGR GTSTYDGMAL AQAMTEYIHN RIGAKTLFST
HYHELTVLDE ELNRLKNVHV SAIEQNGKVV FLHKIKEGAA DKSYGIHVAE LAELPKEVIR
RANEILHALE DKAEEMDKKA NEKAGKLEKV SEHSTLIMDQ QQQVNEEAQL SLFVEVEKPK
KKDFDSKERK VLEQIKELNL LDMTPLQAMN TLYELHKKIK G
//
