ID N1J6Y6_BLUG1 Unreviewed; 621 AA.
AC N1J6Y6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=L-ornithine N(5)-monooxygenase {ECO:0000256|ARBA:ARBA00018612};
DE EC=1.14.13.196 {ECO:0000256|ARBA:ARBA00012881};
DE AltName: Full=L-ornithine N(5)-oxygenase {ECO:0000256|ARBA:ARBA00030351};
GN ORFNames=BGHDH14_bgh01020 {ECO:0000313|EMBL:CCU75541.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU75541.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU75541.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU75541.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC NAD(+); Xref=Rhea:RHEA:41512, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:78275; EC=1.14.13.196;
CC Evidence={ECO:0000256|ARBA:ARBA00001398};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC NADP(+); Xref=Rhea:RHEA:41508, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:78275; EC=1.14.13.196;
CC Evidence={ECO:0000256|ARBA:ARBA00001847};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU75541.1}.
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DR EMBL; CAUH01001447; CCU75541.1; -; Genomic_DNA.
DR AlphaFoldDB; N1J6Y6; -.
DR STRING; 546991.N1J6Y6; -.
DR eggNOG; KOG1399; Eukaryota.
DR HOGENOM; CLU_006937_7_0_1; -.
DR InParanoid; N1J6Y6; -.
DR OrthoDB; 49786at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42877; -; 1.
DR PANTHER; PTHR42877:SF5; L-ORNITHINE N(5)-OXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:CCU75541.1};
KW Oxidoreductase {ECO:0000313|EMBL:CCU75541.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441}.
SQ SEQUENCE 621 AA; 70311 MW; 9DD8E18D37C834D1 CRC64;
MVFGSDPNRI AANGKIIRRH HGLASENYTY YPLVIIGAGK SGISMGCRLK AELGFDQFRI
FERQNGIGGR WWINRHPGNT CDIPGVLYSF PFYPSSKMTT LPPSGNEIIE YLEDACMQYQ
LVDKIQLNTE VEGCRWLASE SLWEVTLRHL ILGAEELNEH KPNQRIKESE PESGYSREKI
RVKVLVSAVG CPSKPEELSN EIPGKDVFKG EIFHSSRWRY DVDLKDKEII VVGTGSSAAQ
FVPLLIREYE ARSVTQLMRS PPWVSPLSTS PFLSDWNKRI RWLVTHVPSV GLLARYIIAI
GAEYEWQLSL DSSSCDMQRR QELEANLLEH MKKTVPKKYH EILTPNYAIK RNNRIFDDAW
LSSLNNPAVV LTTLPLTHLG EHDITLGPGR TYPDPKDTSS RAPSHKVTIP ADIIIFANEL
SSGSWTYPFE VVGQDGKKLH DMSAEIEGPQ MYMGTVMGGF PNFFAISGPN KMLCHSPFSL
ATENAINLSL KLIKPLLLND LTTVEFKKQP EIDWTQEVQN STDNSKLISS NQDSCSPIKT
DHNPLFYPMF PTWSDWNMVY TSKGLVKNTA KKALKALTIT FMFWSIIEMR SVRGPFLILR
RPIRWALLNS SKVLLCASQK I
//
