ID N1JF09_BLUG1 Unreviewed; 1121 AA.
AC N1JF09;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=ATP-dependent helicase NAM7 {ECO:0000313|EMBL:CCU76368.1};
GN ORFNames=BGHDH14_bgh05848 {ECO:0000313|EMBL:CCU76368.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU76368.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU76368.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU76368.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU76368.1}.
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DR EMBL; CAUH01002404; CCU76368.1; -; Genomic_DNA.
DR AlphaFoldDB; N1JF09; -.
DR STRING; 546991.N1JF09; -.
DR EnsemblFungi; BLGH_05494-mRNA-1; BLGH_05494-mRNA-1; BLGH_05494.
DR eggNOG; KOG1802; Eukaryota.
DR HOGENOM; CLU_001666_4_0_1; -.
DR InParanoid; N1JF09; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:CCU76368.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000313|EMBL:CCU76368.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 90..247
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 98..130
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 112..140
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 158..188
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 972..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 123493 MW; C6738C8F1E67505F CRC64;
MEGAFTHLGN HLISDSAAAI NAGADDLSSI DPDESLLYGQ YGGRDGLSTN RRRNDDDDND
TEVFDDDAES LASVPVDGMK NLSLRRVEDE KELPSHACAY CGIHSPSCVV KCLGCSKWFC
SARGNATSSH IVNHLVRARH KEVQLHPLST LGDTVLECYN CGTKNVFLLG FIPAKSDTVV
VLLCRQPCAS TPSSKDMSWD ISRWQPLIED RSFLPWLLSV PTDAEQLRAR HLTPPMIAKL
EEMWKDNASA TIADLEKAAG IDDDPAPVLL KYDDAYQYQN VFGPLVKIEA DYDRKLKEAQ
SEDGLVIRWD LGLNNKHLAS FVLPKIELGD VKLAVGDEMR LKYKGELRPV WEGVGYVVKI
PNNQSDEVTI ELRKVGSDKS VPTECTHNFS ADYVWKATSY DRMQFAMKTF AVDEMSVSGY
IFHKLLGHEV AAAPMKIQMP KKFSVPGLPE LNSSQISAVK SVLQKPLSLI QGPPGTGKTV
TSATVIYHLS KVNGGQVLVC APSNVAVDQL CERIHRTGLK VVRLTAKSRE DVESSVGFLA
LHEQVRMNDS NVELMKLAQL KTELGELSSQ DEKKFKALTR AAEREILTNA DVICCTCVGA
GDPRLAKMKF RTVLIDESTQ SAEPECMIPL VLGCKQVVLV GDHQQLGPVI MNKKAAKAGL
NQSLFERLVM LEMHPIRLNI QYRMHPCLSE FPSNMFYEGT LQNGVTMQER LRYEVDFPWP
VGDTPMMFWS NLGNEEISAS GTSYLNRTEA SNVEKIVTRF FKAGVQPDDI GVITPYEGQR
SYVVSSMQNT GTFKKESYRE IEVASVDAFQ GREKDFIVLS CVRSNDHQGI GFLSDPRRLN
VALTRAKYGL VILGNPKVLS KHPLWHHLLL HFKERNCLVE GPLSNLQTSL LQFSRPKTTY
RGPQRYQMSH PVFNGHLTAN GKGISDFSDA GSMLGYIADD VSSIHSSALG GVGLGSAYPQ
MFSNFVPEAW PGLDPRTRQN GQKLRGRAPE SIAGESVAAS ELTDATGSTF DGKGMGQGGV
SLGPSHHDVQ KQTSLNQSDR LKRYVESGGR IADYKMSDTA SVFGSSSLLS GRRLDDDEKS
VSTAFASQIG GTTRSRWLSA DTPASSRALD HQWTPPDVTD E
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