ID N1JFW6_BLUG1 Unreviewed; 987 AA.
AC N1JFW6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=DNA mismatch repair protein Msh5 {ECO:0000313|EMBL:CCU76777.1};
GN ORFNames=BGHDH14_bghG003027000002001 {ECO:0000313|EMBL:CCU76777.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU76777.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU76777.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU76777.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU76777.1}.
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DR EMBL; CAUH01003027; CCU76777.1; -; Genomic_DNA.
DR AlphaFoldDB; N1JFW6; -.
DR STRING; 546991.N1JFW6; -.
DR eggNOG; KOG0221; Eukaryota.
DR HOGENOM; CLU_002472_8_0_1; -.
DR InParanoid; N1JFW6; -.
DR OrthoDB; 9867at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03281; ABC_MSH5_euk; 1.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441}.
FT DOMAIN 802..818
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 110445 MW; EC48FC59EBB8FD55 CRC64;
MDEFKSKRRR LDTPASSVHT SNSSTPYEKS SSPLQLIRES KTASTLRLSS LPSQKRCSTA
VSVRDPQESL LTQDDDIIRT VGAEIGSHSL SHHDTDEISE VILAIDMRDR GVIGCAYYEF
CEQKLYLMEE IKMGRLDLVD TLKIHVQPTT ILISTRTDED LEKHLSHDAR GIDRESEENN
ISGSYGLEYR PSSDFSFEQA KYKLINLDLD SEHDHDMMFT TPNDNLGILG SRSFMGRQGR
LLRLASCINL ESRLTVGCAG AILNYLSRCR NTQCIPTIQE DQTRFQVRAI QMFTLSNMMF
INADTFASLQ IMQSKNHPNI HMQGPNQSNS GAKESLSVFG LFSNFARTPQ GKQRLRQVFL
EPSIDITAIE ERLETISVLL RPENSVSLVQ LHSHLKMIKN IRTIVIHLQK GISDSSRKGN
AIRKSVWGSL QNFVLRFLKL LDAIRELNGY ETLSITKKFF TEVESTKITE VGIMINDTVD
FQTSDDVHRT AVLQGVDTEL DELKRTYDGM DSLLTQVANQ ISADVPEWAA QYIENCIFFP
QLGFLVVVAL DPGTGLGKYE GEGLDDDSWE KKFVSDNMGY YKNKRMEQMD EYFGDMYGII
CGRYSPSLIP GFKTNKEDRE IEIIHMLAVT ILERKKLLTT ASDLCGELDS FLALALGAQK
YQFIQPKITT ANIIHIEGGR HPLQELSVPT YIPNPCFITG GPGNNEINVP ESASPEKTTH
PGMLILTGPN YSGKSVYLKQ NALIVYMAHI GSFVPADSAI IGLTDKIMTR ITTRESVSRN
QSAFMIDLQQ ISLALSLATR RSLIIIDEFG KGTSASDGAG LCCGVFEYLL SLGTERPKVL
GATHNHEIFE NGYLSKRPGL EFGHMEVRVE KDVDAKVDQI TYLYNFVLGR STSSFGTYCA
LMNGIEKAIV ERAEELILLE ARGEDLMAAC ATVSADEIRE LEDAEEVGRR FLEHKKLLEP
GLQESELPSE ASIHKILRGI LGYQQEA
//
