ID N1PW95_DOTSN Unreviewed; 834 AA.
AC N1PW95;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 03-MAY-2023, entry version 34.
DE RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN ORFNames=DOTSEDRAFT_78000 {ECO:0000313|EMBL:EME47796.1};
OS Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS fungus) (Mycosphaerella pini).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX NCBI_TaxID=675120 {ECO:0000313|EMBL:EME47796.1, ECO:0000313|Proteomes:UP000016933};
RN [1] {ECO:0000313|Proteomes:UP000016933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT but also signatures of common ancestry.";
RL PLoS Genet. 8:E1003088-E1003088(2012).
RN [2] {ECO:0000313|EMBL:EME47796.1, ECO:0000313|Proteomes:UP000016933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC biogenesis, stability and to maintain vacuole morphology.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR EMBL; KB446536; EME47796.1; -; Genomic_DNA.
DR AlphaFoldDB; N1PW95; -.
DR STRING; 675120.N1PW95; -.
DR EnsemblFungi; EME47796; EME47796; DOTSEDRAFT_78000.
DR eggNOG; KOG2280; Eukaryota.
DR HOGENOM; CLU_008909_1_0_1; -.
DR OMA; HMTIRDH; -.
DR OrthoDB; 1110811at2759; -.
DR Proteomes; UP000016933; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000016933};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 8..413
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 506..815
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 834 AA; 93892 MW; 63E03B973EF326E7 CRC64;
MSKPLAPRAN WERIGDRFYR KIQLYDNLFD PDLELENYTV TGAPYSGAVA LRRDESHIYS
LRGSQAIKST IDTYSCAGKL IRQIPWDTGS IKSVGWSEEE RLLIVTDDGT VRVYADLQDD
FAQFSLGHGA EEHGVQSCKF WSTGFVALLG NNSVVVVARY DEPRPQLLTS APPGDVHSWT
LIPPEYTSSR SVEVLLAIDK TVYVVDAVEA EDRGLEAGPF RHIRVSPNGK FIALYTDDGK
VWVISADFQE RFSEYDTKAR TPPKDMEWCG DNAVAIAWED EVHLIGPHGA AWKLQDYTSF
VHLLPDVDGL RIMNNDVCEF LQKVDPDTTE EVFKLGSDAP AAVLLDAIEQ LENKSPKADD
NIQLIRQNLD EAVDVCVRAA GKEYSIHWQK QLLKAASFGK SVLELYNSDD FVDMTEALRV
LNAVRFFEVG LPLSYEQYIR LTPERLIQRL VNRQEYLLAL KISEYLHLPS DRIYVSWARQ
KVCGSSASED SICAEIVRKL NGKRGVSFEE VARASYNEGR HDLATRLLEH EPRAGKQVPL
LLSIGEESIA LDKAIESGDT DLVFYVLLSL KKKIPLSSFF RTINSRPMAT AIVEASAIDQ
DQELLKDFYY QDDRRLDGAN LLISEALAAS DVGPANDKLK MAAKLLRDSK EFAPQVTAIE
ESQKLLRLQE HFEKELSDRY VGLSINATLS KLIKTGNMKR SSKLQSEFKV TDKTYWWVRL
RALVSRRDWR ELEEISKNKK SPIGWEASPL SLPFFNEILG AGNPKVASVF IPKCTSLTPA
ERIEMWVKCG LVTRAAEEAL KARDRAALDE LRTKASGQGV LEIDRMIAQL QKGR
//
