ID   N1QJ27_SPHMS            Unreviewed;       385 AA.
AC   N1QJ27;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=C-3 sterol dehydrogenase/C-4 decarboxylase family protein {ECO:0000313|EMBL:EMF17180.1};
GN   ORFNames=SEPMUDRAFT_146281 {ECO:0000313|EMBL:EMF17180.1};
OS   Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria
OS   musiva).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Sphaerulina.
OX   NCBI_TaxID=692275 {ECO:0000313|EMBL:EMF17180.1, ECO:0000313|Proteomes:UP000016931};
RN   [1] {ECO:0000313|EMBL:EMF17180.1, ECO:0000313|Proteomes:UP000016931}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SO2202 {ECO:0000313|EMBL:EMF17180.1,
RC   ECO:0000313|Proteomes:UP000016931};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; KB456260; EMF17180.1; -; Genomic_DNA.
DR   RefSeq; XP_016765301.1; XM_016903549.1.
DR   AlphaFoldDB; N1QJ27; -.
DR   STRING; 692275.N1QJ27; -.
DR   GeneID; 27900686; -.
DR   eggNOG; KOG1430; Eukaryota.
DR   HOGENOM; CLU_007383_6_8_1; -.
DR   OMA; STAHWFD; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000016931; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016931}.
FT   DOMAIN          16..288
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   385 AA;  42586 MW;  190C5F75C8AD0CA0 CRC64;
     MAGSNAPKMR SLGHVLVTGG AGFLGNHIVK MLAERNACDR ITVLDLRPPT APIASVDYQQ
     GDLTDYEQMR PLFDAGHFDA VIHTASPVMT ASKNREVMRK VNVEGTRVLL RAAQETGVRA
     FVYTSSASVI HDTQSDLVYA DETYPLIMGK QQPEYYTTTK AEAELLVLAA NRSPQYPHLL
     TAAMRPSGIF GEGDVQVLPP GLSAYYKGQT KVQIGSNENL FDFTEVTNVA HAHHLATAAL
     LATADRDAQG LAPPLDHERV DGEAFFITND APVYFFDFAR MCWAAAGDTT RPEQVWILSK
     DVGLFLATLM EWIFFLFRLG KPNLTRQQVR YTCMTRYYNI EKAKKRLGYA PLVGLQEGIR
     RGVADALYRG VVVGQPQELK GKKLQ
//