ID N1R743_FUSC4 Unreviewed; 1012 AA.
AC N1R743;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN ORFNames=FOC4_g10011984 {ECO:0000313|EMBL:EMT60704.1};
OS Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=2502994 {ECO:0000313|EMBL:EMT60704.1, ECO:0000313|Proteomes:UP000016929};
RN [1] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000256|ARBA:ARBA00002558}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; KB726997; EMT60704.1; -; Genomic_DNA.
DR AlphaFoldDB; N1R743; -.
DR STRING; 1229665.N1R743; -.
DR HOGENOM; CLU_003212_0_0_1; -.
DR Proteomes; UP000016929; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW Protease {ECO:0000256|ARBA:ARBA00022825};
KW Reference proteome {ECO:0000313|Proteomes:UP000016929};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 390..466
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT DOMAIN 865..942
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 112214 MW; 8949DFD5D32F1B4B CRC64;
MNGANSSARA KRKAPGSPGE APPSKRPING KHSPNDNTPD IIEFDDNSDM TDELHPHAMY
IGTPGSLGEW QDTIQKVVRN VVAIRFCQTC SFDTDSALTS EATGYVVDSE KGYILTNRHV
VGAGPFWGHC VFDNHEEVDC YPVYRDPVHD FGILRYDPKA IKYMHIDGLE LRPDLAKVGT
EIRVVGNDAG EKLSILSGII SRLDRNAPEY GEGYSDFNTC YYQANAAASG GSSGSPVVNK
DGCAVALQAG GRSDGASTDY FLPLDRPLRA LQCIQNGKPV TRGDIQCQFL LKPFDECRRL
GLSPHWEAAM REKFPEETNM LVAEIVLPQG PSDKKIEEGD VLIKVNGELI TQFIRLDDIL
DSSVGETIKL HLQRGGQDVE VEIEVGDLHK ITPDRFVSVA GASFHDLSYQ QARLYAVAVK
GVYVCESAGS FRFDNTDNGW IVQSIDHKKV PDLDTFIQVM KAIPDRARVV VTYKHLRDLH
TLNTTVAYID RHWAAKMKLA VRNDETGVWD FTDLGDPLPP VPPTRRSASF IELDHMPHQG
IADLIRSFVH INCTMPLKLD GFPKNRRWGM GLVIDADKGL VLISRAIVPY DLCDITVTIA
DSIIVEGKVV FLHPLQNYAI IQYDPSLVDA PVMSARLSNE VLTQGAKTYF LGYNRIGRVV
HGSTSVTEIT AVAIPANSGA PRYRAVNVDA ITIDSNLGST CNSGVLVAPD GTVQALWLSY
LGERSHHTSR DEEYYLGLGT KTLLPVVESV QKGINPKLRI LSVEFRSVQM AQASVMGVSD
EWIKKVTQTN RSHHQLFMVS KRTFERENHP VSLLEGDIIL TLNGKICTTI SDFDLMYSHE
LLDAVIVREC EEMHLQLPTV AADDMETNHA VSFCGAILHR PHQAVRQQIS KLHSEVYVSS
RIRGSPAYQY GVAPTNFITH VNGTPTPDLD SFIAATREIP DNTYFRLKAV TFDCVPWVIT
MKKNDHYFPT MEWIKDDKEA CGWRRVTYEG SEVFKGEATD GVVPVAQDAD ME
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