ID N1RLY1_FUSC4 Unreviewed; 1229 AA.
AC N1RLY1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Checkpoint serine/threonine-protein kinase bub1 {ECO:0000313|EMBL:EMT66769.1};
GN ORFNames=FOC4_g10003102 {ECO:0000313|EMBL:EMT66769.1};
OS Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=2502994 {ECO:0000313|EMBL:EMT66769.1, ECO:0000313|Proteomes:UP000016929};
RN [1] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
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DR EMBL; KB726987; EMT66769.1; -; Genomic_DNA.
DR AlphaFoldDB; N1RLY1; -.
DR STRING; 1229665.N1RLY1; -.
DR HOGENOM; CLU_002115_1_0_1; -.
DR Proteomes; UP000016929; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13981; STKc_Bub1_BubR1; 1.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR012572; Mad3/Bub1_II.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14030:SF4; BUB1 KINASE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR Pfam; PF08171; Mad3_BUB1_II; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EMT66769.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016929};
KW Transferase {ECO:0000313|EMBL:EMT66769.1}.
FT DOMAIN 63..226
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 882..1229
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 237..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 136393 MW; 3F5B6F626BF445B1 CRC64;
MSASGDLIDF DLIEGQKENI QSLPGGRSAK KLAELYSPSP LHKLSTPTPS DTRNVNDCIR
AEFEQEVENI AESDDPLDVF ERYVRWTLDA YPSAQATPQS QLHTLLERAT KTFIGSAQYK
NDPRYLKLWV HYIHFFSDTP RETYMFLSRH GIGESLALFY EEYAAWLEGA NRWAQAEEVY
KLGIDREARP VQRLIRKFKE FEQRVAQQPD VMNEPSSPAL PTMRPALAAK VDPFAAARAA
DPQAPRPSSG GAGKPSKSKL AIFSDADAQP SAMSSMSAGS KGWDSIGSLA DRRKENAVEA
KPWAGETLPA GGKKSTASKM SVFRDPSLSQ IQNIVVVPSK HQISVHPQTG KKERVFVDLA
AIYPTPEEIG TELSFEEIMA ADRGWLDHCW EDETFDENLV PEPVMPLEIE EISKGAGERL
MIHQDPVDRL PIHQDPVGKL AIHKDTVEKL VIHQDSSTTL AVHKDTVQYD ENGKAVEQHR
GPRGGKKKKM IEVNETQIIK AKLDSPSRPK LKKKNTSEPT MTLHTKAATD DIYDIFNAPL
KPAGQEEEDE ESADDDDYES DDNYTTDAES TGTTRHIEPS EAGDDENDET SDVKSVSEWS
DFSTRRHIPH IDGEDDGDEG TERNETQVSD SIDTGAPGPD QESSEAFDST DQQTGTGEEQ
NDDAEELETP VSEDFPPTAR TTFVPIPPED YEPPTRPFRD PAEVANNRLP FMTPITERTE
VSLDVTMERR GYKTPSKKDN SPTIDEEDEG SSDSEPLSSP LREMANDPIP PPKMSAPLAP
KSIGPLGKAI PPKPLAPKGP IIKDAQCNPV DESVRSEIIS RMLPPLSSYS GFYDHRHEKY
ERGAEIRKFA KALAKANKSG DNKTGPVAAP VVIELPGTPS TYTIKKELGA GAFAPVYLVE
NSAPEADEND ENAIPTMGKG AFAVSHRSEI EALKMENPPT PWEFHMMRLA HTRLGPQHRT
SASLSYAHEM HLFQDEAFLF LPYHPHGTLL DVVNFFRAEP SAVMDEQLAM FFTIELLRTV
EALHSKSILH GDLKADNCLL RLDALSDDES LTAQWKADGS GGWSSRGVVL IDFGRGIDMR
AFVPEVEFIA DWKTSAQDCA EMREGRPWTW QIDYHGLAGT IHTLLFGKYI ETVRCDQGGL
GKSGRRYKIR ESLKRYWQTD LWSDCFELLL NPGAAAAAGG EDGGKMPVLK SMKNVRERME
TWLGANCERG VGLKSVMGRL EATFGKNRK
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