ID N1RSC5_FUSC4 Unreviewed; 766 AA.
AC N1RSC5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Exosome complex exonuclease rrp6 {ECO:0000313|EMBL:EMT68251.1};
GN ORFNames=FOC4_g10012664 {ECO:0000313|EMBL:EMT68251.1};
OS Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=2502994 {ECO:0000313|EMBL:EMT68251.1, ECO:0000313|Proteomes:UP000016929};
RN [1] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; KB726554; EMT68251.1; -; Genomic_DNA.
DR AlphaFoldDB; N1RSC5; -.
DR STRING; 1229665.N1RSC5; -.
DR HOGENOM; CLU_010129_0_0_1; -.
DR Proteomes; UP000016929; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:EMT68251.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:EMT68251.1};
KW Nuclease {ECO:0000313|EMBL:EMT68251.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016929};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 405..485
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 111..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..636
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 87290 MW; CBC8DF384DBDF14F CRC64;
MEQSQDFKSL QESVQKSLIS TIKTVNRIAA EDLSFQRTVN PSVGQLLEDR TSRILELSTQ
LLLTAGKACG VKAPKLEDVE DIEMKWRGVV DVVDSSLEKA DTALDEYTGL VKRKEPPLPD
PANKSKKPKS TNKGIRNANM TKPQLLFERK PDNFAPAPWK PMLTSKPNAK LSLEESLNVV
PNEAGTPQYQ HPYEHEIVRM SYPKRVFKES EPIMYQPVET TEATFVDTYE GVLEMLEELK
GAKEIAIDLE HHDFRSYVGL VSLMQISTRE KDWIVDTLQP WRHKLEVLNQ VFTDPNVVKV
FHGAYMDMVW LQRDLGLIRP LPEEMMYYAR SDTHYLLYIY DRVRNELVAA SDRGDVDKDY
IGRAVEKSKE QSLSRYEHPG YDEETGEGSR GWYGYIFKNS HLAFDSEQFA VFRALWKWRD
NTARKEDEST NYVLSTRDIT EIARINPPDA KALHSLLPLN ASLARPRFNE IWEQIKETKA
KGGLSLLHFF TSMAPDSVRK NGMPIAARKT TKLPDLDGEV TVSRLTRSQL FGDMPISSKW
DPSTRPTETE EELIPFPWQR FIQQGSIKGD VQHDTAAEEV NVSEQTDTVE SAVGNAEVEE
ADEEFTLRRG QKRKSQAIEE SEPSEEDTDP SQYDSDEEMQ EGGGVIAVED EPSQKASRSA
RRKLRKAEEK KAEEERLRRQ EVKKVRKAQK KQKKQDDKTK KFDAVPFDYS KATSVLHSNR
ESNGGQADGK GKKKVFDPYS KSADTDIKGA RKAPPVRGER SATFKN
//
