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Database: UniProt
Entry: N1RUS8_FUSC4
LinkDB: N1RUS8_FUSC4
Original site: N1RUS8_FUSC4 
ID   N1RUS8_FUSC4            Unreviewed;      1450 AA.
AC   N1RUS8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   31-JUL-2019, entry version 30.
DE   SubName: Full=Urease {ECO:0000313|EMBL:EMT69639.1};
GN   ORFNames=FOC4_g10003373 {ECO:0000313|EMBL:EMT69639.1};
OS   Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Fusarium; Fusarium oxysporum species complex.
OX   NCBI_TaxID=1229665 {ECO:0000313|EMBL:EMT69639.1, ECO:0000313|Proteomes:UP000016929};
RN   [1] {ECO:0000313|Proteomes:UP000016929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA   Fang X., Huang J.;
RT   "Genome sequencing and comparative transcriptomics of race 1 and race
RT   4 of banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000016929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX   PubMed=24743270;
RA   Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA   Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA   Fang X., Peng M., Huang J.;
RT   "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT   oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL   PLoS ONE 9:E95543-E95543(2014).
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR611612-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR611612-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR611612-50}.
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DR   EMBL; KB726365; EMT69639.1; -; Genomic_DNA.
DR   EnsemblFungi; EMT69639; EMT69639; FOC4_g10003373.
DR   Proteomes; UP000016929; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0043419; P:urea catabolic process; IEA:InterPro.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PRINTS; PR01752; UREASE.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016929};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016929}.
FT   DOMAIN      494    897       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   REGION      926    952       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   ACT_SITE    678    678       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       499    499       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       501    501       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       575    575       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       575    575       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       604    604       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       630    630       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       718    718       Nickel 1. {ECO:0000256|PIRSR:PIRSR611612-
FT                                51}.
FT   BINDING     577    577       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     575    575       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR611612-50}.
SQ   SEQUENCE   1450 AA;  158776 MW;  1BC0A02CB7EF70AF CRC64;
     MAFISPSPQS SIESSIHLYC NGNVLYNHKD RGLLSNPYQH PSAQDTGFNF TPLNKDCSAI
     LHSKKLAKCT TRPVRYIFLN PCALLILTSW LQVEKLLFSQ AGRLAQRRLA HGKKLNHLES
     SIIHNEDYSV ADLMKLGKGI LGRRHVHPSV AGTLKQMQVE GTFKTGTHLI TIHNPISTDE
     GDLKMALYGS FLPIPTSDLF PPVNEADFHP LAMPGAIRPA DTGDIVLNAS RNRVRLTITN
     QGTRAVHVGH YTPRYVFCRT NVGYQIGSHF HFMETNPDLD FDRGKAYGYH LDLPAGEFLR
     FEPNEPKTVT LVQVGGSRII QGGSGYAKGP VDPTNVQKIL QQLQQAGYRH SLEGSTGQQT
     VKPCSISREK YASAYGPTTG DLIRLGSTDL WVKVEKDYTS YGDECTLGCG KTIRDGMGAA
     SGCSDADCLD LAIINAVIID WTGIFKADIG VKDGAIVGIG KAGNPATMDG VSDNMVIGSN
     TDIIDAGGKI VTAGGIDTHV HNICPQQAFE AISSGGTGPS TSSTAVNGTA SKKYIRQMMQ
     ACDQLPLNFG LVGKGSDSEI VGLLDQIKAG VIALKLHEDF GCTPSTIDNC LNVCEEQDIQ
     CHIHTDGLNE AGFLEHTAAI FKGRSIHVYH VEGAGGGHAP DVIKLVAYPN VLPSSTTPTM
     PFTTNTIDEH IDMAANCHRL SKDNPDDASF LKNRIREETI SAEDIFHDIG AISIMSSDSQ
     AMGRSAEVLT CTWKAAHKNK VQRGPLNEDK DTGADNFRVK RFISKYTINP AITQGISHAV
     GSVEAGKLAD LVVWDPAEFG TKPFQVLKKG FITYAQMGDP NGAVADVEPL IGRPMYGALH
     PESSVMFVSQ ASIAQGGDVH SYNLKKQIEV VKNCRTVKKC DLKYNSATPK VEVDPETLVS
     SIFTDVDGRI MANHSIETAC TFVGRSRRTT RQNRARSVST SAHSPAVNHA SHDNTFDIDN
     SFDTGHIPAQ HASSQAPTIF AATPPVLSHQ SQVPYHQAST LGSVATTTQL QFSKSLDDIN
     GQTSILLGAS SESDPWLLRH CQFDEYGLRS FYGLQFRNIG GVPNRQKIPV HFIVRQDETD
     VIDASLRARL NELIPVSWGL RLIRLNDDHL SIVDMHNQLP LEAVWRLVHE SLQVEIRHPQ
     LCVLQAGLFY LHGIGQDHQP LSTAPDAFKW SWLGSLVGMA HNLGLHLETR MCAIPTEEKQ
     LRARLWWALY TEDKWLSLLM GRPPYISEDE WDVSPLEESD FSVPISVPFA DVIHAELTRP
     FRDMSRLSAI ASLVQSSFYS LKASQKLSEN LSLSIQIAQP IFEQLSLWRA SVLAPESPTI
     TSNNGMLNDK ASYPATILVA HATLVTYVWR ALLRPIVPSA LPPLIVDDQQ LAEASLFMEL
     QPHDIENLCW DLPDLSHLEL PLRSTVDGTG SHGAVTQNLH QSSLAWATSL SSLVKNLSPA
     RFHEFWYSCE
//
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