ID N1RVM8_FUSC4 Unreviewed; 2633 AA.
AC N1RVM8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Dedicator of cytokinesis protein 1 {ECO:0000313|EMBL:EMT68217.1};
GN ORFNames=FOC4_g10012629 {ECO:0000313|EMBL:EMT68217.1};
OS Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=2502994 {ECO:0000313|EMBL:EMT68217.1, ECO:0000313|Proteomes:UP000016929};
RN [1] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; KB726554; EMT68217.1; -; Genomic_DNA.
DR STRING; 1229665.N1RVM8; -.
DR HOGENOM; CLU_000595_0_1_1; -.
DR Proteomes; UP000016929; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 2.
DR Gene3D; 1.25.40.410; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 2.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016929};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..87
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 615..797
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1445..1857
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT DOMAIN 2048..2460
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 89..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1857..1887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1911..2028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2460..2493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2514..2633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1862..1887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2465..2493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2550..2575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2633 AA; 294784 MW; AA2C65E65CBA93DB CRC64;
MPWQPLPRIA FAVATYPFPA SSPADLPLEI GDELYIIEET PDGNWLRGYL VAPPSLLAGL
TSVKGQTLEA RVFSGIFPRS CVEVREMLGE PEEGDENEDA ASDGPALDGD MPRASDSAKS
GVTNISARKS RKDGNRSTIS SKGRTPFKEL PNGTLGSLSI PVDRDPNAPR PAAPVPMLKI
GDETPTSLSE PLIDEIASCL REWHSTNLHE LLLSRQYSRL DQLSQLITGL NLHRQQFLYN
VLTAHEYDRL RERTVWDLVR VNKLCGGEVI VRDPEARGRV LTADDCIVKV TKLQSVMSLL
DEPPQSLAEL TALHHLMVDI KGFAGASIEE TSLVFYLVSK PQYGQPTTLS EGFTVKIPAG
GTIVNLAKHA QTKTLFTDLS SQDVGDVPSA ETELFLVVKV LASQQIIPSQ PLSRSGTGPT
APYSRDHMKP TSSGGMKSTR RSLMWGGKSS RSGISRGSPV TRMDAVAEQN DERLSTSGAE
SREGTGPPST AGSKTGSPPD GVQIADRTIG LGILRLNPIM KQDDEVEHLV NIWSTSSRHA
GEKDTGDDWD PLVKELLDSP SGHYEKSRRG ERLQLQLKSF NHSDADILIK STPTMLSGVT
KTSKMGFSGA PTRPRSDIYL TLTDAALGKQ NLLSRFGGSA TAMPSSVHGN NLQITLEVRK
TSGERIENCI FASSNTEALS TFKSIATERG EPWNQTLRLA LAPNEVPQAH VVMFVSDMPN
PPFAIGHMPL WDQGAFIRDG LHGLLLYKID EHTSTAQPGP TGKGGYLSLS WSPQGKDDHP
VEVTGPLAVL RIDTYLCSTR FSQDRVILGL LKWRDLQREE VPGVLRQLIF VPEIEVVKLL
SDVLDGLFGI LVEYSGSHEF EDLVFTALVR VLGIVHDRRF NLGPLVDQYA ENQFNYPFAT
PCLMRSFTRL LQNPTEPETA RKLRATFKVV RHILKFITHA RTQQKEKEAG IGITSNTTGF
TRELRAIFKA LDAMMRNSAP ALVGTQTLAV QHFHTWLPEL AGLLTTEEIL HIAIDFMDSC
TDVKGKLVLY KLVLIINYGK LDLFAHPDQK LALSTNTVRW ITPHWGHSEE VTDQWRDQIR
LCCSILASQI DYLGSEIPDH IPKIIDSYLA ILAAPRTPKD RLSLLFPSSY PFPTKPVNED
LQFDEALVEL SAILSAISNS PSGMQLELAE DDLTTLLENL LRVHMSILKG EAYPLGWLSV
HIHHHKSTMR TLEYLAGTML EAFLPDPEEA ESFNTELWKL FFTTLLKLVG STSLALETFP
EQKRRAVWKI AGDVREHGAE LLRRTWEAIG WETTPDERSR YNLSKMGGYQ VQYVPALVGP
IVELCLSVHE GLRRMAVEVL QTMIVSEWTL SEDLSIIQTE TIDRLDLFFK EKPLTESTLQ
KLFIPELLER FEPLAEIPDE PLYTALREFV GTIDEFLDLL VAVHSSEDTG EATHLINRLR
LMEFLRDMQK EEIFVRYVHQ LADLQAESRN HTEAGLALRL HADLYEWDPA SQTSALPDPE
FPAQTQFERK ERLYFDMIKY FEEGESWSHA LAAYKELQTQ YETNIFDFSK LARTERAIAT
IYETISKTDK LVPKYFKVVY KGLGFHANLR DKEYIYEGSP SERASAFTDR MQEQYPAAQI
VTGGDVDDVE GQFLVISAVT PHRDLSHHVF QRARVPQVIR DFLLSSHPQT FSISTRRNTN
GPVKEHSAEK LVFTTADAFP TILRRSEVVD TQEIRLSAHE TALERIVRKT QEMTALEHRV
ADGNGDHAQL LLDAVSVSVN PTSESSVACY RQLLPEPKEV NDDAEEDEDQ EASEVELTPQ
DSAIKMALVD HAIMIKRCLA MFARSPNEIL NSRYEELHRF FESTFASEIA HFTPPQPQRE
MVATPSPTWR RSSRSSEASP KHKNIGVSVN GVTTEEASVI RPVSKRGTRL SFLGGSKKKE
PELPTEPEEP AVDIETASNL SRSLSRSQSK EHNRRHSFFR TQSHDEKHPE SPGGFSSRGS
FDQQFGGGNE KAVENKIPSK KGSVRKRFSM LKLGRKGSKG NGMMGSLDEE LFPSSTHLIN
RLRLMEFLRD MQKEEIFVRY VHQLADLQAE SRNHTEAGLA LRLHADLYEW DPASQTSALP
DPEFPAQTQF ERKERLYFDM IKYFEEGESW SHALAAYKEL QTQYETNIFD FSKLARTERA
IATIYETISK TDKLVPKYFK VVYKGLGFHA NLRDKEYIYE GSPSERASAF TDRMQEQYPA
AQIVTGGDVD DVEGQFLVIS AVTPHRDLSH HVFQRARVPQ VIRDFLLSSH PQTFSISTRR
NTNGPVKEHS AEKLVFTTAD AFPTILRRSE VVDTQEIRLS AHETALERIV RKTQEMTALE
HRVADGNGDH AQLLLDAVSV SVNPTSESSV ACYRQLLPEP KEVNDDAEED EDQEASEVEL
TPQDSAIKMA LVDHAIMIKR CLAMFARSPN EILNSRYEEL HRFFESTFAS EIAHFTPPQP
QREMVATPSP TWRRSSRSSE ASPKHKNIGV SVNGVTTEEA SVIRPVSKRG TRLSFLGGSK
KKEPELPTEP EEPAVDIETA SNLSRSLSRS QSKEHNRRHS FFRTQSHDEK HPESPGGFSS
RGSFDQQFGG GNEKAVENKI PSKKGSVRKR FSMLKLGRKG SKGNGMMGSL DEE
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