ID N1RXL9_FUSC4 Unreviewed; 577 AA.
AC N1RXL9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 08-NOV-2023, entry version 32.
DE SubName: Full=Beta,beta-carotene 15,15'-monooxygenase {ECO:0000313|EMBL:EMT70604.1};
GN ORFNames=FOC4_g10009069 {ECO:0000313|EMBL:EMT70604.1};
OS Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=2502994 {ECO:0000313|EMBL:EMT70604.1, ECO:0000313|Proteomes:UP000016929};
RN [1] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
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DR EMBL; KB726312; EMT70604.1; -; Genomic_DNA.
DR AlphaFoldDB; N1RXL9; -.
DR STRING; 1229665.N1RXL9; -.
DR HOGENOM; CLU_016472_5_0_1; -.
DR Proteomes; UP000016929; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Monooxygenase {ECO:0000313|EMBL:EMT70604.1};
KW Oxidoreductase {ECO:0000313|EMBL:EMT70604.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016929}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 239
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 291
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 361
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 570
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 577 AA; 64597 MW; 3AB4C8133C7D1210 CRC64;
MALNGPGVYH RTREHEQEDA SNITKNILAQ SWKSWPNEAA FDRLEEHRGP LRLTVRGTFP
SWAAGSLYRT GPGQSRVEDT ARGTHFTTHW FDGFAQTHRF DIIPSEDDET QVWYSSRRQA
DEWIADVKKK GWRSGMTFGQ KADPCVGIFA KVMTVFEPKL GNHNVALLAN VPGVPEDEKT
EVSNGVTGPL GHRVNTSNLF VSTDYTGIRR IDPSTLQPLG ETTQYDLHPS LSGPCSCSHA
QRDPDSGDLF NFNLAFGRVP TYRIFRVDAA SGETEVLATI SDLNVPPAYM HSFFLTENHV
VICIPASHYA WRGLKTQWEG NIIDSMKPFD KERKCKWLVV DRRHGKGLVA TFSTPAAFFF
HSINAFEEKV KDEDGAEQTD LFFDMAKYEN MDIIKGFYYD VLMDRDDATK KYWFKNDRYK
NCAPTLTRYR FRLPPKPAPD TTFSASAEEV LAIPSPHAGE LPTIHPLRNG KPYRYVYSAS
LRGLTTSVDA LVKTDLDTSE AFIWTGPEGH TPGEPVFVPR PGAVEEDDGI IFSLVVDGVN
EAAYILCLNG KTMEEMGRAE ADFAIGQGFH GIHLPAA
//
