ID N1ZEJ8_9CLOT Unreviewed; 471 AA.
AC N1ZEJ8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Amino acid carrier protein {ECO:0000313|EMBL:EMZ14281.1};
DE SubName: Full=Amino-acid carrier protein AlsT {ECO:0000313|EMBL:USF28841.1};
DE SubName: Full=Sodium:alanine symporter family protein {ECO:0000313|EMBL:NDO46719.1};
GN Name=alsT_1 {ECO:0000313|EMBL:USF28841.1};
GN ORFNames=C820_000215 {ECO:0000313|EMBL:USF28841.1}, C820_01548
GN {ECO:0000313|EMBL:EMZ14281.1}, FMM67_07675
GN {ECO:0000313|EMBL:NDO46719.1};
OS Clostridium sp. MD294.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=97138 {ECO:0000313|EMBL:EMZ14281.1};
RN [1] {ECO:0000313|EMBL:EMZ14281.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF356 {ECO:0000313|EMBL:EMZ14281.1};
RX PubMed=24723722;
RA Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT community from gnotobiotic mice.";
RL Genome Announc. 2:e00287-e00214(2014).
RN [2] {ECO:0000313|EMBL:NDO46719.1, ECO:0000313|Proteomes:UP000462571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF356 {ECO:0000313|Proteomes:UP000462571}, and MD294
RC {ECO:0000313|EMBL:NDO46719.1};
RA Elie C., Mathieu A., Saliou A., Darnaud M., Leulier F., Tamellini A.;
RT "Draft genome sequences of 15 bacterial species constituting the stable
RT defined intestinal microbiota of the GM15 gnotobiotic mouse model.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:USF28841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ASF356 {ECO:0000313|EMBL:USF28841.1};
RA Proctor A., Parvinroo S., Richie T., Jia X., Lee S.T.M., Karp P.D.,
RA Paley S., Kostic A.D., Pierre J.F., Wannemuehler M.J., Phillips G.J.;
RT "Resources to Facilitate Use of the Altered Schaedler Flora (ASF) Mouse
RT Model to Study Microbiome Function.";
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC ECO:0000256|RuleBase:RU363064}.
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DR EMBL; AQFQ01000012; EMZ14281.1; -; Genomic_DNA.
DR EMBL; VIRC01000013; NDO46719.1; -; Genomic_DNA.
DR EMBL; CP097810; USF28841.1; -; Genomic_DNA.
DR RefSeq; WP_004036110.1; NZ_VIRC01000013.1.
DR AlphaFoldDB; N1ZEJ8; -.
DR STRING; 97138.C820_01548; -.
DR PATRIC; fig|97138.3.peg.1555; -.
DR eggNOG; COG1115; Bacteria.
DR HOGENOM; CLU_024867_1_0_9; -.
DR OrthoDB; 9804874at2; -.
DR Proteomes; UP000012445; Chromosome.
DR Proteomes; UP000462571; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR001463; Na/Ala_symport.
DR NCBIfam; TIGR00835; agcS; 1.
DR PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR Pfam; PF01235; Na_Ala_symp; 1.
DR PRINTS; PR00175; NAALASMPORT.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363064};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW Reference proteome {ECO:0000313|Proteomes:UP000012445};
KW Symport {ECO:0000256|RuleBase:RU363064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363064};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363064};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT TRANSMEM 18..37
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 220..243
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 315..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
SQ SEQUENCE 471 AA; 49545 MW; 94E8F5D2958B7720 CRC64;
MTEFAETLNG YVSIVNGWVW GPVMLILLFG THLFLTIRTR VIQLHIFKAI KLSVTKDSAA
EGDISQFGAL TTALAATIGT GNIVGVATAV AAGGPGAVLW CWLTGVVGIA TKYGEALLAV
KYRVKTNDGS MLGGPMYALE LGVGEHYGKL FGRVLGIVFA LLAGIAAFGI GNMTQGNSIS
VMVQDTFGVS PIVTGLILMI LTGVVVIGGV KSIAKVCEKL VPLMAFFYII GCIVIIFINH
SYIVPALKEI FSSAFSARAM GGGFVGATVI TAARYGIARG LFSNESGLGS APIAAAAAQT
RNPVRQALVG MTGTFWDTVI VCALTGIVLV SSIIKDPASL EGLSGGNLTS AAFNAIPGVG
PVVLTIGLIT FAWSTILGWS YYGERAWEYL AGKKAVFPFR VVWVIVVFIG CVTALDLVWN
IADTLNACMA FPNLVSLLLL SGVIVNETKK YLWENNLDAT STDIILQIDK N
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