ID N1ZNV3_9CLOT Unreviewed; 774 AA.
AC N1ZNV3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) {ECO:0000256|ARBA:ARBA00014333};
DE AltName: Full=Cyclic oligoadenylate synthase {ECO:0000256|ARBA:ARBA00032922};
GN Name=cas10 {ECO:0000313|EMBL:NDO45316.1};
GN ORFNames=C820_00069 {ECO:0000313|EMBL:EMZ15708.1}, C820_002493
GN {ECO:0000313|EMBL:USF31047.1}, FMM67_00385
GN {ECO:0000313|EMBL:NDO45316.1};
OS Clostridium sp. MD294.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=97138 {ECO:0000313|EMBL:EMZ15708.1};
RN [1] {ECO:0000313|EMBL:EMZ15708.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF356 {ECO:0000313|EMBL:EMZ15708.1};
RX PubMed=24723722;
RA Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT community from gnotobiotic mice.";
RL Genome Announc. 2:e00287-e00214(2014).
RN [2] {ECO:0000313|EMBL:NDO45316.1, ECO:0000313|Proteomes:UP000462571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF356 {ECO:0000313|Proteomes:UP000462571}, and MD294
RC {ECO:0000313|EMBL:NDO45316.1};
RA Elie C., Mathieu A., Saliou A., Darnaud M., Leulier F., Tamellini A.;
RT "Draft genome sequences of 15 bacterial species constituting the stable
RT defined intestinal microbiota of the GM15 gnotobiotic mouse model.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:USF31047.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ASF356 {ECO:0000313|EMBL:USF31047.1};
RA Proctor A., Parvinroo S., Richie T., Jia X., Lee S.T.M., Karp P.D.,
RA Paley S., Kostic A.D., Pierre J.F., Wannemuehler M.J., Phillips G.J.;
RT "Resources to Facilitate Use of the Altered Schaedler Flora (ASF) Mouse
RT Model to Study Microbiome Function.";
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- SIMILARITY: Belongs to the CRISPR-associated Cas10/Csm1 family.
CC {ECO:0000256|ARBA:ARBA00005700}.
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DR EMBL; AQFQ01000003; EMZ15708.1; -; Genomic_DNA.
DR EMBL; VIRC01000002; NDO45316.1; -; Genomic_DNA.
DR EMBL; CP097810; USF31047.1; -; Genomic_DNA.
DR RefSeq; WP_004033280.1; NZ_VIRC01000002.1.
DR AlphaFoldDB; N1ZNV3; -.
DR STRING; 97138.C820_00069; -.
DR PATRIC; fig|97138.3.peg.70; -.
DR eggNOG; COG1353; Bacteria.
DR HOGENOM; CLU_017487_1_0_9; -.
DR OrthoDB; 9768769at2; -.
DR Proteomes; UP000012445; Chromosome.
DR Proteomes; UP000462571; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09680; Cas10_III; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR013408; Cas10/Csm1.
DR InterPro; IPR048693; Cmr2-like_C.
DR InterPro; IPR041062; Csm1_B.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR02578; cas_TM1811_Csm1; 1.
DR PANTHER; PTHR36528; CRISPR SYSTEM SINGLE-STRAND-SPECIFIC DEOXYRIBONUCLEASE CAS10/CSM1 (SUBTYPE III-A); 1.
DR PANTHER; PTHR36528:SF1; CRISPR SYSTEM SINGLE-STRAND-SPECIFIC DEOXYRIBONUCLEASE CAS10_CSM1 (SUBTYPE III-A); 1.
DR Pfam; PF20824; Cmr2_hel_dom2; 1.
DR Pfam; PF18211; Csm1_B; 1.
DR Pfam; PF01966; HD; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:USF31047.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000012445}.
FT DOMAIN 503..655
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 774 AA; 88706 MW; 9A97952C7E944FC3 CRC64;
MNDTEYLITI GGLLHDVGKL LYRYNDKRNH SISGFEFIQK EADINDVNIL EQIHYHHAAL
LKNAKLADNS LAYITCIADN ISAAADRRKS NEEGWGFVRE IPLESIFNRL NGNDENKKYP
PAMLDKGINY PIDEKNKTIK YNQEFYGKCV NNIKNCIKAI EYDENYINSL LEVLEANISF
IPSSTSINEV ADISLFDHSK TTAAIACCIY QYLKQNNIIN YKSELFLKSN DFYHKKVFLL
YSMDISGIQD FIYTISTDKA LKNLRARSFY IELIMEHIID ELLCTLSLSR ANLLYCGGGH
AYMILSNTEK TIKVISDYEK EINDWFLKNF GTALYIAGGF ASCSANDLKN EPQGSYGDIF
KNVSNNISQK KSSRYTASDI IKLNDNTTDG ERECSVCRKT EKLNDNQRCS ICEVLENFSN
DIINKQFFSV VKKSQGLPMP RNMYILADDK RSLIQKMTKE NYVRAYCKNK MHTGFNIVCK
LWVGDYKNGD TFEDLAKAAN GIARLGVLRA DIDNLGQAFV CGFESNKNKD TYVTISRTAT
FSRKLSMFFK LHINEILANG QYCTISDKEG ERNIAIVYSG GDDVFVVGAW DDVIEFAIDL
NDALSDYAQG TLTISAGIGI YPQKYPISTM AIQTGELEEL SKQYPDKNAI TLFGEGNTYH
WDTFVNDVLE DKYLTIKDFF ESIENKNSST ARGKAFLYRL LELMKNREEK INLARFAYVL
SRLQPNEEED KQASENYNQF AKKMYHWIRD EEQCRQVITA IYIYIYSIRE REEE
//
