ID N1ZU56_9FIRM Unreviewed; 718 AA.
AC N1ZU56;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=BIG2 domain-containing protein {ECO:0000259|SMART:SM00635};
GN ORFNames=C823_06028 {ECO:0000313|EMBL:EMZ17365.1};
OS Eubacterium plexicaudatum ASF492.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1235802 {ECO:0000313|EMBL:EMZ17365.1, ECO:0000313|Proteomes:UP000012589};
RN [1] {ECO:0000313|EMBL:EMZ17365.1, ECO:0000313|Proteomes:UP000012589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF492 {ECO:0000313|EMBL:EMZ17365.1,
RC ECO:0000313|Proteomes:UP000012589};
RX PubMed=24723722;
RA Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT community from gnotobiotic mice.";
RL Genome Announc. 2:e00287-e00214(2014).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMZ17365.1}.
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DR EMBL; AQFT01000209; EMZ17365.1; -; Genomic_DNA.
DR AlphaFoldDB; N1ZU56; -.
DR STRING; 1235802.C823_06028; -.
DR PATRIC; fig|1235802.3.peg.6364; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG5492; Bacteria.
DR HOGENOM; CLU_384842_0_0_9; -.
DR OrthoDB; 1767185at2; -.
DR Proteomes; UP000012589; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00635; BID_2; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000012589};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..718
FT /note="BIG2 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004114356"
FT DOMAIN 629..709
FT /note="BIG2"
FT /evidence="ECO:0000259|SMART:SM00635"
FT ACT_SITE 178
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 223
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 572
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 718 AA; 77769 MW; 6F732821B196F875 CRC64;
MNKRKIVAWL LAATAVIWQT APVCAAALQT QAHEVEVPQL EEGTYVKGEA LVSMTTTQAA
ALTKEGTASF DKDIRVEECW EFGTAQDAQS EQIKDYVALV SSDTYSTKEL MEIAADRYYV
DAVAPNSYAH LCDIGKDTLS DYQWYLDGTG SFRTESKGIR FSDLEAESFM QPVVALIDTG
VDYTNEDLKD SMWVNPYQSK GVEGTYGYDF ANDDDDPMDT DGHGTHCAGV IAAQQNNAAG
ITGISNAKIM ALKVVKDNSD VFDVAGAIRA FEYIVRAQEM GVPVAAVNCS WGGSRDSGAV
LNTLIDKMGA NGALTVFAAG NDSIDWDAIP MSLRTVPYDL DSKYVVVAGA SDENDERVYF
SDYGNTQVDL FAPGSNIVST VQEAKFLPQF WTPEKRQQMT TYYNTVSSID DFYTASNIRG
LGSDYTVRLS YEPKVGCSDQ TDGSLKYTVK NNRSFGLPIV KDDIFDGGME QAGFIYLDVT
DWNPDTEKTY YISCMMADND GDGVPAWESV EKVSTKDDCR FVTSGGRTYL ALIGITTQKT
RSTTYYFDNF AVSVADPDTD QFEKCDIMSG SSMAAPMVTG AVAVLRGVNP TYDAMGIRSL
LMECTRSVDA LENACVTGGI LDLSGIVVQP TSLKLNKASA NVRYGNKLQL VATILPENAA
GANVTWKSSN PAYASVSAKG VVKVKKAGVG KTVKITASTK DGIKLQDACT VKILKAKK
//
