ID   N2APT8_9LACO            Unreviewed;      1180 AA.
AC   N2APT8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=YSIRK family gram-positive signal peptide {ECO:0000313|EMBL:EMZ26474.1};
GN   ORFNames=C821_00408 {ECO:0000313|EMBL:EMZ26474.1};
OS   Lactobacillus sp. ASF360.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=97137 {ECO:0000313|EMBL:EMZ26474.1, ECO:0000313|Proteomes:UP000012594};
RN   [1] {ECO:0000313|EMBL:EMZ26474.1, ECO:0000313|Proteomes:UP000012594}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ASF360 {ECO:0000313|EMBL:EMZ26474.1,
RC   ECO:0000313|Proteomes:UP000012594};
RX   PubMed=24723722;
RA   Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT   "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT   community from gnotobiotic mice.";
RL   Genome Announc. 2:e00287-e00214(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMZ26474.1}.
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DR   EMBL; AQFR01000016; EMZ26474.1; -; Genomic_DNA.
DR   AlphaFoldDB; N2APT8; -.
DR   STRING; 97137.C821_00408; -.
DR   PATRIC; fig|97137.3.peg.374; -.
DR   eggNOG; COG0810; Bacteria.
DR   HOGENOM; CLU_255566_0_0_9; -.
DR   OrthoDB; 2414228at2; -.
DR   Proteomes; UP000012594; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR011505; Peptidase_M26_C_dom.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   NCBIfam; TIGR01168; YSIRK_signal; 1.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF07580; Peptidase_M26_C; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   4: Predicted;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Secreted {ECO:0000256|ARBA:ARBA00022512};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           38..1180
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004114869"
FT   TRANSMEM        1157..1176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1147..1180
FT                   /note="Gram-positive cocci surface proteins LPxTG"
FT                   /evidence="ECO:0000259|PROSITE:PS50847"
FT   REGION          1034..1062
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1034..1051
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1180 AA;  131288 MW;  A0ED8F85487BBB26 CRC64;
     MQKHSQYRYA LRKLSVGLTS VAVGLAFMAT TTTTVHADSE PQIQTTENQT SENEITVIEN
     TNDNLAKVET VNLQGDGQDD KTSQATADTK TDLDVDTTTD VNQDLKNDQN TVDNEANTLK
     QDTNNKENNI SDATISGQQP VQTEKKVDAD IVKSVTDNLK QVKYDAFDGD PKQVLRNWNH
     IQLTSSSLVD SFNEVYNQLP TLVPQLLEHT DNIDTANQRV SDNAGAIMVG MSYINRWYNV
     SYEDKELLPV MMFDPKAFGS NLDSIDWLSK IGDWSTDELA PSNTVTTFNN KLAPLLNTQS
     DLVTFLGDLR KKWAPDLSDE EWFRSNTGVH IVEVPSKEAP DLNLNIYHRL STNKDLQEYI
     LPLLNVKNDD MYVVSALGMM IFGSYEPYID VKYHKDPVVY QEKVQAVHKE LTRLSTAWRD
     HFDFWYRMAN AEGKRHLTTA NIQVWDSYNA IDSSKKGGRR WLNKRDTDIP AVAEFFGPLG
     KIYEAAGLSA DAVGNAVRYY VAQVANNFGG IGILSHEMTH NFDNSIYLDG FQHRPGTGVE
     TYATGLLESP WDRTFANYGL NTALTFYADN NRTTNKSPAR FQTRKDLQDY MHGIFDITYL
     LDYAEAQAMV GKSAKEKQLM YSQISYDPTK KADVVSGPIS TEIADKLMTI DDFIDNNIIA
     SRGYQAGSYG TNSYQTISMY APDYAAVQSS TSVSGGITFK KTAFELLAAK GWADGFISYI
     TNKYAKDAKN DKKSLSDTYA LAKIFNGEYD NDYATFKKAM FKERIDKRQD FKPITITLNS
     KNIQLNNWDE LQNLMQTTVD QELALRAQGK KSSLINDLKA AILTAELKQT EDFRSSIFAS
     PQQSKQGEIV GEGTSLDWPA YDLNSLKKGK VVDEGTKLEV PAYDLTSLKK GVVVDEGAQL
     ELPDYDLNSL KKGEAVGGGT KLDLPAYDLN ALKKGEAVGE GTKLDLPVYD LNLLKKGEAV
     GEGTQLELPT YDLDLLKKGE VVGEGTKLAL LAYDLNSLKK GELVSDSTQF DLPVYDVASL
     KKNEIVSEDA SSNLPSLQIN DSKNAQESAA EKLSAQDDDS ATKLDVTENE QKDQLKGNVP
     SSTLSSLNVK ISEKKIEISS NNRSPEINNY KHIISRIKNH KLTKSVKLNA KIKNHHVFSN
     FKNNVSLPQA GSKNDNIFLL LAGIISLFTA LGLSIFKKKK
//