ID N2B4E2_9FIRM Unreviewed; 713 AA.
AC N2B4E2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=C823_01571 {ECO:0000313|EMBL:EMZ31534.1};
OS Eubacterium plexicaudatum ASF492.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1235802 {ECO:0000313|EMBL:EMZ31534.1, ECO:0000313|Proteomes:UP000012589};
RN [1] {ECO:0000313|EMBL:EMZ31534.1, ECO:0000313|Proteomes:UP000012589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF492 {ECO:0000313|EMBL:EMZ31534.1,
RC ECO:0000313|Proteomes:UP000012589};
RX PubMed=24723722;
RA Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT community from gnotobiotic mice.";
RL Genome Announc. 2:e00287-e00214(2014).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMZ31534.1}.
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DR EMBL; AQFT01000047; EMZ31534.1; -; Genomic_DNA.
DR AlphaFoldDB; N2B4E2; -.
DR STRING; 1235802.C823_01571; -.
DR REBASE; 86204; M2.Epl492ORF1570P.
DR PATRIC; fig|1235802.3.peg.1670; -.
DR eggNOG; COG0270; Bacteria.
DR HOGENOM; CLU_006958_13_0_9; -.
DR Proteomes; UP000012589; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 2.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000012589};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 713 AA; 76305 MW; 459C411A01018C94 CRC64;
MNADAMYTHS REPGSCGGDT PNPQSADSRL TLGSLFDGSG GFPLGGLLAG ITPLWASEIE
PFPIRVTTKR LPFVKHLGDI SAVDGTGIDP VDIITFGSPC TDMSVAGKRA GLGGQQSCLF
YQAIRIVKEM RCATDGKYPR FIVWENVPGA FSSNKGEDFK AVLEAVCSVK GGDIPVPGPP
KGKWANAGSI VADGFSLAWR VLDAQFWGIP QRRKRIYLVA DFAGGSAGKV LFESEGVSGY
SAEGFRAWQG AAGGAADCTG AAGGICLNDQ GGQRMDVTDD VTCTLRAEAH HPPCVLESAG
FCTEHSAKAR GIGYEEETSP TLRAGTVPAA VALYENHSQD TRYTGPLDTA PTVSSTYGMG
GNNQPFVVET PKTLKIRSGC EGGGKGAIIQ DDKSATLSCN NDQTVFVPFC KGCRAHYKGD
APTWKDGKVA NTLNTFDVGE SRCNELVVQA YGICSKDSNA MKSDNPHSGF YEADTSRTLD
GNGGNPSCNQ GGIAVVSVQG SMIGRDDKNG PQGSGVNEDV SFTLNATDHH AVAYPTYCTS
KNSHFTRAEK ELANTLVATD YKDPPVINDV QTASGKEVFG TLSASMGSKQ WLGNQEAFSG
DYHIMEPEYI VRRLTPTECA RLQGFPDWWC SGLGTEEPTE DDLAFWREVF EAHRRIAGTS
TKPKTDKQII KWLKDPHSDS AEYKMWGNGV ALPNVYFVLS GIVYYAQFPD FLL
//
