ID N2B5Z8_9FIRM Unreviewed; 438 AA.
AC N2B5Z8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=C823_00928 {ECO:0000313|EMBL:EMZ35856.1};
OS Eubacterium plexicaudatum ASF492.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1235802 {ECO:0000313|EMBL:EMZ35856.1, ECO:0000313|Proteomes:UP000012589};
RN [1] {ECO:0000313|EMBL:EMZ35856.1, ECO:0000313|Proteomes:UP000012589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF492 {ECO:0000313|EMBL:EMZ35856.1,
RC ECO:0000313|Proteomes:UP000012589};
RX PubMed=24723722;
RA Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT community from gnotobiotic mice.";
RL Genome Announc. 2:e00287-e00214(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMZ35856.1}.
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DR EMBL; AQFT01000024; EMZ35856.1; -; Genomic_DNA.
DR RefSeq; WP_004053821.1; NZ_AQFT02000001.1.
DR AlphaFoldDB; N2B5Z8; -.
DR STRING; 1235802.C823_00928; -.
DR GeneID; 78432273; -.
DR PATRIC; fig|1235802.3.peg.996; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_2_1_9; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000012589; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000012589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 150..253
FT /note="UvrA DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF17755"
SQ SEQUENCE 438 AA; 48929 MW; A3C3F7337C38BE2D CRC64;
MEKIIIKDAY ENNLKHLDIQ IPLDAFTCVT GCSGCGKSSL VFDTLYAESQ RGFLEGMTGN
IYSQKLMNKP KVMSIENLRP ALNISQNYYN VNPRSTIGTI TEISYYLRTL FSLVNSDAKI
GISENIFSSN NPKTFCPNCN GLGVEMVVSP ELLIPDPDKT LRDGAILYFK GSAESKEQKC
LEAICDHYGI DIDKKYSDLT KNEINMLLYT EEVLKVKISY KDGKRKKQHF VSIQGVIPLL
KKNFSSADSK AQAAPYSKYV ETTACHVCNG AKLGQKALAY TLGGLNYHEI ESLEITSLKS
WLENLKDKRI TEEKKVLVEQ LKDSILQKVK ALIELNVGYL CLNRSVPSLS GGERQRVRIA
KQLTCPLKGL IYILDEPCKG LHHRDIVHII DATRNLIQKG NTVIAIEHDK QYISKADYRI
ELGPVGGPEG GYLISSDD
//
